|
|||||
|
|
| IL-18对SLE患者外周血淋巴细胞凋亡及相关基因表达的研究 | |
| 引用本文： | 李富荣,叶志中,戴勇,陈晓琳,洪小平,谭艳红,王新根.IL-18对SLE患者外周血淋巴细胞凋亡及相关基因表达的研究[J].现代免疫学,2001,21(5):264-265. |
| 作者姓名： | 李富荣 叶志中 戴勇 陈晓琳 洪小平 谭艳红 王新根 |
| 作者单位： | 1. 深圳市人民医院(暨南大学医学院第二附属医院)临床医学研究中心, 2. 深圳市人民医院(暨南大学医学院第二附属医院)临床医学研究中心风湿免疫科, 3. 深圳市人民医院,暨南大学医学院第二附属医院,临床医学研究中心, |
| 摘 要： | 本文研究SLE患者外周血淋巴细胞 (PBL )在IL 18刺激下细胞凋亡及凋亡相关基因表达情况。采用AnnexinV联合PI染色定量法及免疫荧光染色法。结果显示在IL 18刺激培养作用下 ,活动期SLE患者PBL凋亡发生率明显增高 (P <0 0 1) ,而静止期则无明显区别 (P >0 0 5 ) ,疾病活动性与PBL凋亡率呈正相关 (P <0 0 1)。Bcl 2表达活动期显著性升高 (P <0 0 5 ) ,静止期无明显著性差异 (P >0 0 5 )。Fas表达活动期显著升高 (P <0 0 0 1,静止期明显升高 (P <0 0 5 )。IL 18可引起SLE患者PBL凋亡率的增高 ,并导致调节紊乱 ,故在SLE发病机制中起作用 |
| 关 键 词： | 系统性红斑狼疮 淋巴细胞 IL18 凋亡 Bcl2 Fas |
| 文章编号： | 1001-2478(2001)05-0264-03 |
| 修稿时间： | 2000年12月26 |
Study on Apoptosis and Expression of the Apoptotic Genes in Peripheral Blood Lymphocytes of Patients with SLE Stimulated by IL-18 |
|
| LI Fu rong ,YE Zhi zhong ,DAI Yong ,CHEN Xiao ling ,HONG Xiao ping ,TAN Yan hong ,WANG Xin geng.Study on Apoptosis and Expression of the Apoptotic Genes in Peripheral Blood Lymphocytes of Patients with SLE Stimulated by IL-18[J].Current Immunology,2001,21(5):264-265. | |
| Authors: | LI Fu rong YE Zhi zhong DAI Yong CHEN Xiao ling HONG Xiao ping TAN Yan hong WANG Xin geng |
| Institution: | LI Fu rong 1,YE Zhi zhong 2,DAI Yong 1,CHEN Xiao ling 1,HONG Xiao ping 2,TAN Yan hong 2,WANG Xin geng 1 |
| Abstract: | The apoptosis and the expression of the apoptotic genes in PBL of patients with SLE stimulated by IL 18 were studied in 18 active SLE and 31 inactive cases by using annexin V united PI staining and immunofluorescence staining method It was found that the percentage of apoptosis in PBL of active cases stimulated by IL 18 was significantly higher than those of controls There was significant correlation between apoptotic percentage from SLE patients stimulated by IL 18 and the activities of disease Expression of Bcl 2 and Fas significantly elevated in active cases but showed no changes in inactive cases It concludes that IL 18 can induce increase of apoptotic percentage in patients with SLE,inducing disturbance of immunoregulation,and might play some role in the pathogenesis of SLE |
| Keywords: | SLE PBL IL 18 apoptosis Bcl 2 Fas |
| 本文献已被 万方数据 等数据库收录！ | |