Negative regulation of TCR signaling and T-cell activation by selective protein degradation |
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| Authors: | Jang Ihn-Kyung Gu Hua |
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| Affiliation: | Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA. |
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| Abstract: | Protein degradation was previously considered to be a nonspecific cellular process that eradicated abnormal or damaged proteins. Current evidence indicates, however, that T cells use this mechanism to selectively eliminate activated T-cell receptors (TCRs) and signaling molecules, and consequently control the duration and specificity of TCR signaling. |
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