Immune protective effect of a moisturizer with DNA repair ingredients |
| |
Authors: | Lucas Cheré R Ke Malcolm S Matsui Mary S Maes Daniel Cooper Kevin D Stevens Seth R Baron Elma D |
| |
Institution: | Department of Dermatology, University Hospitals of Cleveland/Case Western Reserve University, Cleveland, OH; Estée Lauder Companies, New York; Cleveland VA Medical Center, Cleveland, OH |
| |
Abstract: | Ultraviolet (UV) light damages DNA and impairs immune surveillance. The faulty repair of DNA after UV exposure is associated with immune suppression and facilitates photodamage that leads to photoaged skin and the growth of skin cancer. Sunscreens have been developed to filter UV light from entering the skin, but are not beneficial once DNA damage has occurred. Enhancing DNA repair after UV radiation may provide added advantage and prevent UV immunosuppression. This study was performed to determine whether a product with DNA repair ingredients prevents UV-induced suppression of contact hypersensitivity responses in vivo . Solar simulated radiation was delivered on skin with and without topical treatment with a moisturizer containing DNA repair enzymes (Advanced Night Repair Concentrate). Subjects were then sensitized to the hapten dinitrochlorobenzene, and the level of resultant contact hypersensitivity response was elicited 2 weeks later. Contact hypersensitivity response measured by skin fold thickness was significantly suppressed in untreated UV-irradiated subjects but not in subjects treated with DNA repair moisturizer after solar simulated radiation. Our results indicate that DNA repair ingredients significantly prevent UV-induced immune suppression. |
| |
Keywords: | DNA damage DNA repair enzyme dinitrochlorobenzene immunosuppression photoprotection ultraviolet |
本文献已被 PubMed 等数据库收录! |
|