| 新型提神醒脑药物莫达非尼的合成 |
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| 引用本文： | 穆报春,雷光清,何小伟.新型提神醒脑药物莫达非尼的合成[J].中国药物化学杂志,1999,9(2):132-134. |
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| 作者姓名： | 穆报春 雷光清 何小伟 |
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| 作者单位： | 中国人民解放军药物化学研究所 |
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| 摘 要： | 以二苯甲基氯和巯基乙酸乙酯为起始原料，经醚化，氨解，氧化三步反应得到新型提神醒脑药物莫达非尼（１），总收率：４１％，实验结果表明：该方法具有合成路线短，反应条件温和，产物易纯化，收率高等优点，完全适合工业化生产。
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| 关 键 词： | 莫达非尼 中枢兴奋药物 合成 |
Synthetic Studies on the Novel Central Stimulant Modafinil |
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| Mu Baochun,Lei Guangqing,He Xiaowei,Du Xiubao.Synthetic Studies on the Novel Central Stimulant Modafinil[J].Chinese Journal of Medicinal Chemistry,1999,9(2):132-134. |
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| Authors: | Mu Baochun Lei Guangqing He Xiaowei Du Xiubao |
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| Abstract: | Modafinil,a new stimulant with vigilancepromoting properties,was synthesised from chlorodiphenylmethane and ethyl 2mercaptoacetate by a newly designed route in which three steps were included.The total yield was 41%.The results indicated that the new synthesis course was better than that reported in literature and may be applied to industrial production. |
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| Keywords: | Modafinil central stimulant synthesis |
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