糖尿病视网膜病变患者红细胞膜Ca~(2 )-Mg~(2 )-ATPase活性变化及相关研究

目的探讨糖尿病视网膜病变发生发展的有关因素。对40例糖尿病机网膜病变患者红细胞膜Ca~(2 )－Mg~(2 )－ATPasc活性进行了检测，并与红细胞内Ca~(2 )－Ms~(2 )－ATPasc含量、空腹血糖、糖基化血红蛋白及红细胞变形指数等进行了分析。结果糖尿病机网膜病变患者红细胞膜Ca~(2 )－Ms~(2 )－ATPasc活性显著下降（P＜0．01），细胞内Ca~(2 )含量增加（P＜0．01）而Mg~(2 )含量则显著下降（P＜0．01）。糖尿病视网膜病变者红细胞膜Ca~(2 )－Ms~(2 )－ATPasc活性下降与空腹血糖、糖基化血红蛋白、红细胞变形指数及红细胞内Ca~(2 )－Ms~(2 )－ATPasc含量等变化密切相关。结论糖尿病视网膜病变患者红细胞膜Ca~(2 )－Ms~(2 )－ATPasc活性异常下降可能是导致或加速视网膜病变发生发展的原因之一。

A study of Ca~(2 )-Mg~(2 )-ATpase Activity in Erythrocyte Membrane from Diabetic Retinopathy Patients

To study the correlative factor about the occurrence and development of diabetic retinopathy(DR). Methods Ca~(2 )-Mg~(2 )-ATPase activity in ery-throcyte membrane was investigated in 40 Patients with DR. The relation of Ca~(2 )-Mg~(2 )-ATPase activity with content Ca2 and Mg2 in erythrocyte, fasting biood -glucoae (FBG ), hemoglobin glycosylation (HBAlc ), and erythrocythe filterability index (EFI)was also studied.Results Ca~(2 )-Mg~(2 )-ATPase activity in reythrocyte membrane was singnificantly decreased in DR (P <0. 01 ). The defect was acconipaned by, an increase in erythrocyte Ca2t (P < 0.01 )2nd a decrease in erytho-cyte Mg' (P <0. 01). The decrease of Ca~(2 )-Mg~(2 )-ATPase activity in erythrocyte in DR was connected with the cllanges of FBG, HbAlc, EFI, and the content of Ca2 and Mg2 in erythrocyte. Conclusiou The de-crease of Ca~(2 )-Mg~(2 )-ATPase activity in erythrocyte membrane may contribute to the occurrence and devel-opment of DR.