Oral and maxillofacial manifestations of Gardner's syndrome associated with growth hormone deficiency: case report and literature review. |
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Authors: | Luca Ramaglia Fabio Morgese Mariagiovanna Filippella Annamaria Colao |
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Institution: | Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali, University of Naples Federico II, Naples, Italy. luca.ramaglia@unina.it |
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Abstract: | Gardner's syndrome (GS) is a hereditary disorder inherited as autosomal dominant with complete penetrance and variable expression. GS is a variant of familial adenomatous polyposis characterized by extracolonic manifestations including osteomas, dental anomalies, and epidermoid cysts. The association between GS and endocrine abnormalities has been well documented but a direct pituitary involvement has never been reported. We present a case of oral and maxillofacial manifestations in an adult patient affected by GS associated with growth hormone deficiency, a hitherto unreported association. The possible pathogenic mechanisms are discussed. |
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