Mutation of NMDA receptor subunit epsilon 1: effects on audiogenic-like seizures induced by electrical stimulation of the inferior colliculus in mice |
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Authors: | Sakamoto Toshiro Mishina Masayoshi Niki Hiroaki |
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Institution: | Laboratory for Neurobiology of Emotion, Brain Science Institute (BSI), RIKEN, Wako-city, Saitama, Japan. tsakamoto@brain.riken.go.jp |
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Abstract: | It has been shown that the N-methyl-D-asparate (NMDA) receptor in the inferior colliculus is involved in the induction of audiogenic seizures (AGS). In the present study we examined audiogenic-like seizure susceptibility in GluR epsilon 1 null KO adult mice (n=32) and wild-type adult mice (n=28) by electrically stimulating the inferior colliculus (IC). Threshold current intensities of the GluR epsilon 1 KO mice for wild running, clonic and tonic seizures were higher than those of wild-type mice. In addition, the incidence rates of each seizure syndrome in GluR epsilon 1 KO mice were lower than in wild-type mice at each current intensity. These results show that GluR epsilon 1 KO mice were more resistant to audiogenic-like seizures induced by stimulating the IC. Thus, our findings suggest that the GluR epsilon 1 subunit plays an important role in regulating AGS. |
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