甲状腺肿瘤血管内皮生长因子、环氧合酶-2表达和临床意义

目的研究血管内皮生长因子(VEGF)、环氧合酶-2(COX-2)在甲状腺肿瘤中表达和临床意义。方法用免疫组化方法对甲状腺良性肿瘤80例、甲状腺癌107例、正常甲状腺15例行血管内皮生长因子、环氧合酶-2表达的检测,对甲状腺癌患者的淋巴结转移、组织学分型、临床分型、年龄、性别行对比分析。结果甲状腺良性肿瘤、甲状腺癌、正常甲状腺中血管内皮生长因子表达阳性率分别为15.0%,77.6%,6.7%,差异有统计学意义(p<0.05),环氧合酶-2表达阳性率分别为13.8%、64.5%、6.7%,差异有统计学意义(p<0.05)。血管内皮生长因子、环氧合酶-2在甲状腺癌中表达与淋巴结转移、组织病理分型比较差异有统计学意义(p<0.05);在乳头状癌、滤泡状癌、未分化癌、髓样癌中血管内皮生长因子表达阳性率分别为81.3%、69.2%、89.5%、57.1%,环氧合酶-2表达阳性率分别为81.3%、88.5%、89.5%、78.6%。血管内皮生长因子、环氧合酶-2与甲状腺癌患者年龄、性别无关(p>0.05)。甲状腺癌中血管内皮生长因子表达和环氧合酶-2表达呈正相关。结论甲状腺癌的发生、发展中血管内皮生长因子和环氧合酶-2起到重要作用,并存在一些协同作用,联合检测两者能使甲状腺癌在恶性程度和预后判断上提供一些证据。

EXPRESSION OF VEGF,COX -2 IN THYROID TUMOR AND ITS CLINICAL SIGNIFICANCE

Objective To explorer the expression of VEGF, COX - 2 in thyroid tumor and its clinical significance. Methods Expression of VEGF, COX- 2 was detected in 80 cases with thyroid adenomas, 107 cases with thyroid tumor, 15 cases of normal thyroid tissues by immunohistochemical method. Analyze the relationship between VEGF, COX -2 and thyroid tumor lymph node metastasis status, pathological type, age and gender. Results Expression of VEGF in thyroid adenomas, thyroid tumor, normal thyroid tissues was 15.0%, 77. 6% and 6.7% respec- tively, which has significant difference（p 〈 0. 05 ）. Expression of COX -2 in thyroid adenomas, thyroid tumor, normal thyroid tissues was 13.8%, 64. 5% and 6.7% respectively, which has significant difference （p 〈 0. 05 ）. The expression of VEGF, COX - 2 was significant different with lymph node metastasis status and pathological type in thy- roid tumor（p 〈 0. 05 ） , The VEGF expression in papillary thyroid carcinoma, follicular carcinomas, undifferentiated carcinoma, medullary carcinoma was 81.3%, 69. 2%, 89. 5%, 57.1% and COX -2 expression was 81.3%, 88.5%, 89. 5%, 78. 6% respestively. There is no statistical sense difference among age and gender（p 〉0. 05）. Expression of VEGF was positively related to the expression of COX - 2. Conclusion VEGF, COX - 2 play an important role in carcinogenesis and development in thyroid tumor. Combinded detection can provide some evidence for estimation of aggressive degree and progonosis.