多肿瘤标志物联合应用对肝癌的诊断价值

目的探讨多肿瘤标志物联合应用对肝癌的诊断价值。方法选择156例肝癌患者(肝癌组)、148例肝炎患者(肝炎组)及120例同期健康体检者(对照组)作为研究对象,对肝癌组、肝炎组及对照组受试者的甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原199(CA199)、α-L-岩藻糖苷(AFU)等4种肿瘤标志物进行检测,比较其血清水平及异常率。结果肝癌组患者血清AFP、CEA、CA199和AFU水平和异常率均显著高于肝炎组和对照组,差异有统计学意义(P<0.05);原发性肝癌患者血清AFP和AFU的水平高于转移性肝癌患者,血清CEA水平低于转移性肝癌患者,差异均有统计学意义(P<0.05);AFP、CEA、CA199和AFU联合检测对肝癌诊断灵敏度为87.4%。结论 AFP、CEA、CA199和AFU联合检测有利于肝癌的筛查。

Clinical value analysis of multi-tumor markers for diagnosis of liver cancer

Objective To investigate the clinical value of multi-tumor markers for diagnosis of liver cancer. Methods One hundred and fifty-six cases of liver cancer patients, 148 cases of hepatitis and 120 cases of healthy examination persons were taken as research subjects to detect their alpha fetoprotein（ AFP）, carcinoembryonic antigen （CEA）, carbohydrate antigen 199 （CA199） and α-L-fucosidase （AFU） in liver cancer respectively. The serum levels and the abnormal rates of them were compared. Results The levels of AFP, CEA, CA199, AFU and the abnormal rates of them in liver cancer group were higher than those in hepatitis group and control group, the differences were statistically significant （P 〈 0. 05 ）. AFP and AFU serum levels in primary hepatic carcinoma patients were higher while serum CEA level in them was lower than metastatic hepatic car- cinoma patients, the differences were statistically significant （P 〈 O. 05 ）. The sensitivity degree of combined detection of AFP, CEA,CA199 and AFU for liver cancer diagnostic was 87.4%. Conclusion Combined detection of AFP, CEA, CA199 and AFU is beneficial for liver cancer screening and worthy of clinical reference.