| 大鼠视网膜光损伤MDA含量和形态学改变及SOD的治疗作用 |
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| 引用本文： | 张广栋,刘学政,张鹏,朱小红. 大鼠视网膜光损伤MDA含量和形态学改变及SOD的治疗作用[J]. 辽宁医学院学报, 2006, 27(2): 16-18 |
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| 作者姓名： | 张广栋 刘学政 张鹏 朱小红 |
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| 作者单位： | 锦州医学院解剖学教研室,辽宁,锦州,121001;山东省青州市立医院,山东,青州,262500 |
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| 摘 要： | 目的 建立大鼠视网膜光损伤模型.检测视网膜光损伤时丙二醛（MDA）含量的变化和光镜改变,以及超氧化物岐化酶（SOD）的治疗作用.方法用自制光损伤装置建立大鼠视网膜光损伤模型,测定光损伤时不同时间点的MDA含量变化及光镜改变.结果大鼠视网膜光损伤时MDA含量增高,光镜下可见视网膜结构改变.结论SOD对大鼠视网膜光损伤有治疗作用,其机制是通过抗脂质过氧化作用.
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| 关 键 词： | 视网膜光损伤 丙二醛 超氧化物岐化酶 脂质过氧化 |
| 文章编号： | 1000-5161(2006)02-0016-03 |
| 收稿时间： | 2005-09-05 |
| 修稿时间： | 2005-09-05 |
The Content Variation of MDA and Structure Changes of Retinal Photic Injury Rats Observed Through Microscope and the Cure Effect of SOD |
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| ZHANG Guang-dong,LIU Xue-zheng,ZHANG Peng,ZHU Xiao-hong. The Content Variation of MDA and Structure Changes of Retinal Photic Injury Rats Observed Through Microscope and the Cure Effect of SOD[J]. Journal of Liaoning Medical University (LNMU) Bimonthly, 2006, 27(2): 16-18 |
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| Authors: | ZHANG Guang-dong LIU Xue-zheng ZHANG Peng ZHU Xiao-hong |
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| Affiliation: | 1. Department of Anatomy, Jinzhou Medical College, Jinzhou 121001 China; 2. Qingzhou Municipal Hospital of Shandong Province, Qingzhou 262500 China |
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| Abstract: | Objective To establish retinal photic injury model of rat. To observe the content variation of MDA and structure changes of retinal photic injury rats observed through microscope and the cure effect of SOD. Methods Establish retinal photic injury model of rats use self - made light injury structure. Detect the contents variation of MDA and structure changes of retinal structure. Results tsThe contents of MDA increases, the structure changes observed through microscope. Conclusions SOD has the cure effect on rat tetinal photic injury, the mechanism is through anti -lipid peroxidation. |
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| Keywords: | retinal photic injury MDA superoxide dismutase lipid peroxidation |
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