Neurotensin facilitates dopamine release in vitro from rat striatal slices |
| |
| Authors: | Marion E. de Quidt Piers C. Emson |
| |
| Affiliation: | MRC Neurochemical Pharmacology Unit, Medical Research Centre, Hills Road, Cambridge CB2 2QH, U.K. |
| |
| Abstract: | Neurotensin, (0.1-10 microM) stimulated the release of [3H]dopamine from rat striatal slices in a calcium-dependent manner, and potentiated the K+-evoked release of [3H]dopamine and endogenous dopamine. This effect was dose-dependent, (1 nM-1 microM) with an EC50 of approximately 10 nM, and was mediated by means of a receptor of similar structure-activity profile to those described in other tissues. |
| |
| Keywords: | neurotensin dopamine release striatum rat |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
