71例阿奇霉素致药物不良反应患儿相关因素的分析

目的：分析阿奇霉素致药物不良反应（ADR）发生的一般规律和特点,为临床用药提供参考。方法：对苏州大学附属儿童医院2006年1月—2014年6月上报国家药品不良反应监测中心网络平台的阿奇霉素引起的71例药物不良反应报告,并对所致相关因素作了分析。结果：阿奇霉素致ADR的用药途径以静脉给药为主,占94.37%;临床表现以皮肤及其附件损害为主,占60.56%;其次是消化系统症状,占33.80%;无新的和严重的ADR发生。结论：应严格掌握阿奇霉素注射剂的用药指证,以减少ADR的发生率。

Analysis of Related Factors in 71 Children with ADR Caused by Azithromycin

Objective： To analyze the general rule and characteristics of the adverse drug reaction（ADR） of azithromycin, and to provide the reference for the clinical drug use. Methods：To gather statistics and to analyze 71 cases of azithromycin ADR report, which were reported in national adverse drug reactions monitor network fi＇om January 2006 to June 2014 in Children＇s Hospital affiliated to Suzhou University. Results：In the 71 cases of azithromycin ADR report, administrating administered intravenously were accounted for the majority（94.37%）. The most vulnerable system/ organ were skin and its appendages（60.56%）, digestive-system（33.80%）, and no a new and serious ADRs were found. Conclusion ： Indications in the use of azithromycin injection should be controlled strictly to reduce ADRs.