鳗鱼降钙素对绝经后骨质疏松症的疗效观察

目的 探讨鳗鱼降钙素治疗绝经后骨质疏松症的疗效.方法 将70例绝经后骨质疏松症患者随机分为两组,治疗组40例,应用鳗鱼降钙素治疗,20 IU肌注每周一次,疗程6个月;对照组30例.两组均口服钙尔奇D(含元素钙600 mg,维生素D125 IU)每天一片,疗程6个月.两组治疗前后均测定2～4腰椎、骨股颈及wards三角骨密度(bone mineral density,BMD),记录患者临床症状.结果 治疗组2个月后骨痛改善率高于对照组(P<0.01),治疗组患者腰2、腰3、腰椎均值BMD较前明显升高(P<0.05).对照组BMD治疗前后无明显变化(P>0.05).结论 鳗鱼降钙素与钙剂联合应用对治疗绝经后骨质疏松症有减轻疼痛,改善症状,同时增加骨密度作用.

Effects of elcitonin on postmenopausal osteoporosis

Objective To evaluate the effect of elcatonin on postmenopausal osteoporosis patients.Methods Seventy cases of postmenopausal osteoporosis were randomly divided into elcatonin treatment group(n=40) and the control group(n=30).The cases in treatment group were intramuscularly injected elcatonin 20 IU once a week for 6 months continuously.Patients in both two groups were given calcium carbonate vitamin D per day for 6 months.Bone mineral density(BMD) of lumbar spine,neck of femur and region of wards were measured and clinical symptoms were recorded before and after treatments.Results A significant difference in bone pain relieving was found between treatment group and control group after two months treatment(P<0.01).And BMD of lumbar spine(L2,L3,average of) in treatment group increased significantly after treatments(P<0.05).However,BMD had no obvious changes in control group(P>0.05).Conclusion The bone pain can be relieved and BMD will be improved after administration of elcatonin combined with calcium supplement.