谷氨酰胺对猪自体异位节段移植小肠粘膜结构与吸收功能的作用

观察了经肠供给谷氨酰胺，对猪自体异位节段移植小肠粘膜的结构及吸收功能恢复的影响，杂种猪行Ｔｈｉｒｙ－Ｖｅｌｌａ式自体节段小肠移植，分别经移植肠灌注等渗盐水，甘氨酸或谷氨酰胺２１ｄ，观察移植肠对Ｄ－木糖和甘氨酸的吸收，同时行移植肠粘膜活检及组织形态学和粘膜ＤＮＡ、ＲＮＡ含量测定，结果表明，灌注谷氨酰胺能促进移植肠粘膜的吸收功能的恢复，可能与促进细胞肥大有关。

Effects of glutamine on the absorption and structure of heterotopic segmental autotransplanted intestine in the pig

Small bowel transplantation has not been so successful until recently.Significant atrophy and impaired absorption,both of which ocurred in the transplanted small intestine, were the unsolved problems.The purpose of this paper was to study the effects of glutamine(Gln) on the absorption and structure of heterotopic segmental autotransplanted intestine in the pig. Fifteen out bred pigs were underwent segmental small bowel autotransplantation as a Thiry Vella graft and then randomly assigned to be infused with normal saline, glycine (Gly) or L Gln into the graft for 21 days. Graft absorption and mucosa histomorphometry were assessed ,and DNA and RNA quantitations were also performed.The results revealed that infusion of Gln directly into the graft could improve the mucosal structure and absorption of D xylose and Gly by means of hypertrophy.