| 调控缺血性脑卒中小胶质细胞极化的药物研究进展 |
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| 引用本文： | 邓杜萍,范金,谢晓龙,李凌鑫.调控缺血性脑卒中小胶质细胞极化的药物研究进展[J].中国康复理论与实践,2020,26(5):559-562. |
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| 作者姓名： | 邓杜萍 范金 谢晓龙 李凌鑫 |
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| 作者单位： | 1.成都中医药大学养生康复学院,四川成都市 6100752.四川大学华西医院康复科,四川成都市 610041 |
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| 基金项目： | 1.四川省科技厅支撑计划项目(2016SZ0039);2.四川省科技厅重点研发项目(18ZDYF2033) |
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| 摘 要： | 缺血性脑卒中后,小胶质细胞被激活,表现为M1和M2两种极化表型,许多药物可以促进缺血性脑卒中后小胶质细胞由M1型向M2型转化,如芬戈莫德、3-正丁基苯酞及其衍生物、姜黄素、西地那非、Exendin-4、雷公藤红素、Omega-3多元不饱和脂肪酸、Malibatol A、红景天苷等。
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| 关 键 词： | 缺血性脑卒中 小胶质细胞 表型 药物 综述 |
| 收稿时间： | 2019-08-13 |
Advances in Drugs for Microglia Polarization after Ischemic Stroke (review) |
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| DENG Du-ping,FAN Jin,XIE Xiao-long,LI Ling-xin.Advances in Drugs for Microglia Polarization after Ischemic Stroke (review)[J].Chinese Journal of Rehabilitation Theory and Practice,2020,26(5):559-562. |
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| Authors: | DENG Du-ping FAN Jin XIE Xiao-long LI Ling-xin |
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| Institution: | 1. College of Health Care and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China2. Department of Rehabilitation, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China |
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| Abstract: | Microglia cells are activated after ischemic stroke, and polarized phenotypes of M1 and M2. Some drugs, such as fingolimod, 3-N-butylphthalide, curcumin, sildenafil, exendin-4, celastrol, omega-3 fatty acids, malibatol A, salidroside, etc., can transfer the polarization from M1 to M2, and may benefit the outcome of ischemic stroke. |
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| Keywords: | ischemic stroke microglia phenotype drugs review |
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