| 脊髓损伤患者大脑中央前回的代谢改变 |
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| 引用本文： | 李雅静,李建军,高峰,郭韵,刘俊,徐珮珮. 脊髓损伤患者大脑中央前回的代谢改变[J]. 中国康复理论与实践, 2020, 26(4): 382-387. DOI: 10.3969/j.issn.1006-9771.2020.04.003 |
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| 作者姓名： | 李雅静 李建军 高峰 郭韵 刘俊 徐珮珮 |
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| 作者单位： | 1.首都医科大学康复医学院,北京市 1000682.中国康复研究中心北京博爱医院脊柱脊髓神经功能重建科,北京市 1000683.中国康复科学所,北京市 1000684.北京脑重大疾病研究院神经损伤与修复研究所,北京市 1000685.北京市神经损伤与康复重点实验室,北京市 1000686.北京清华长庚医院,北京市 102218 |
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| 基金项目： | 中国康复研究中心课题(No.2018ZX-5);中央级公益性科研院所基本科研业务费专项资金项目(No.2019CZ-1);北京市科技计划重大项目课题(No.D161100002816004);首都卫生发展科研专项项目(No.2018-1-6011)。 |
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| 摘 要： | 目的 观察脊髓损伤患者大脑中央前回初级运动皮质(M1)代谢变化。方法 2018年12月至2019年10月,选择住院脊髓损伤患者20例(患者组)和健康人15例(对照组),使用磁共振波谱(MRS)观察大脑左侧M1感兴趣区氮-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)和肌醇(MI)浓度。结果 患者组MI浓度较对照组明显增高(t = 3.745, P < 0.01),NAA、Cho、Cr、NAA/Cr、Cho/Cr、Cho/NAA与对照组相比无显著性差异( t < 1.431, P > 0.05)。 结论 脊髓损伤患者M1区可能有胶质细胞增生,提示发生代偿性修复。
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| 关 键 词： | 脊髓损伤 磁共振波谱 中央前回 初级运动皮质 神经胶质细胞 增生 修复 |
| 收稿时间： | 2019-11-24 |
Metabolism Levels in Precentral Gyrus of Patients after Spinal Cord Injury |
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| LI Ya-jing,LI Jian-jun,GAO Feng,GUO Yun,LIU Jun,XU Pei-pei. Metabolism Levels in Precentral Gyrus of Patients after Spinal Cord Injury[J]. Chinese Journal of Rehabilitation Theory and Practice, 2020, 26(4): 382-387. DOI: 10.3969/j.issn.1006-9771.2020.04.003 |
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| Authors: | LI Ya-jing LI Jian-jun GAO Feng GUO Yun LIU Jun XU Pei-pei |
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| Affiliation: | (Capital Medical University School of Rehabilitation Medicine,Beijing 100068,China;Department of Spinal and Neural Function Reconstruction,Beijing Bo'ai Hospital,China Rehabilitation Research Center,Beijing 100068,China;China Institute of Rehabilitation Science,Beijing 100068,China;Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing 100068,China;Beijing Key Laboratory of Neural Injury and Rehabilitation,Beijing 100068,China;Beijing Tsinghua Changgeng Hospital,Beijing 102218,China) |
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| Abstract: | Objective To investigate the changes of metabolite concentration in the precentral gyrus(primary motor cortex,M1)in spinal cord injury(SCI)patients.Methods From December,2018 to October,2019,20 SCI patients and 15 healthy controls were scaned with magnetic resonance spectroscopy to measure the concentrations of N-acetylaspartate(NAA),choline(Cho),creatine(Cr)and myo-inositol(MI)in region of interest(ROI)of left M1.Results Concentration of MI was more in the patients than in the controls(t=3.745,P<0.01).There was no significant difference in the concentrations of NAA,Cho and Cr,as well as the ratios of NAA/Cr,Cho/Cr,Cho/NAA between the patients and the controls(t<1.431,P>0.05).Conclusion There may be hyperplasia of glial cells in M1 of SCI patients,indicating compensatory repair in cerebral motor cortex. |
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| Keywords: | spinal cord injury magnetic resonance spectroscopy precentral gyrus primary motor cortex gial cells hyperplasia repair |
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