| 血吸虫病联合用药的研究进展 |
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| 引用本文： | 赵晋英,刘鹏,李艳伟,汪世平.血吸虫病联合用药的研究进展[J].中国寄生虫学与寄生虫病杂志,2020(3):370-377. |
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| 作者姓名： | 赵晋英 刘鹏 李艳伟 汪世平 |
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| 作者单位： | 邵阳学院分子生物学诊断重点实验室;邵阳学院;中南大学湘雅医学院病原生物学系 |
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| 基金项目： | 湖南省教育厅科研项目(No.16C1439)。 |
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| 摘 要： | 目前治疗血吸虫病仍然依赖于吡喹酮单一疗法,尽管吡喹酮可有效杀灭血吸虫成虫,但对幼虫作用弱,且单独使用吡喹酮不能逆转与感染相关的不良病理损害。由于吡喹酮耐药株的出现,亟需寻求可替代的抗血吸虫病药物。当前抗血吸虫病新药研发进展缓慢,但临床前研究和临床试验发现吡喹酮与多种抗疟药物联合应用显示出良好的杀虫效果,与其他辅助药物的联合应用也发挥了协同治疗作用。本文就此方面研究进行综述。
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| 关 键 词： | 血吸虫病 吡喹酮 抗疟药 抗纤维化 抗氧化剂 |
Research progress on combined medications for schistosomiasis |
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| ZHAO Jin-ying,LIU Peng,LI Yan-wei,WANG Shi-ping.Research progress on combined medications for schistosomiasis[J].Chinese Journal of Parasitology and Parasitic Diseases,2020(3):370-377. |
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| Authors: | ZHAO Jin-ying LIU Peng LI Yan-wei WANG Shi-ping |
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| Institution: | (Key Laboratory of Molecular Biology Diagnosis,Shaoyang University,Shaoyang 422000,China;Department of Human Anatomy and Histology and Embryology,Basic Medical College,Shaoyang College,Shaoyang 422000,China;Department of Pathogenic Biology,Xiangya School of Medicine,Central South University,Changsha 410013,China) |
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| Abstract: | Currently,the praziquantel(PZQ)remains the drug of choice for schistosomiasis treatment.Despite its effectiveness in killing adult schistosomes,PZQ is ineffective for schistosomula,and monotherapy using PZQ cannot reverse the pathological damage associated with the infection.With the emerging PZQ-resistant strains,it is imperative to find out alternatives for PZQ.At present,the research and development of new anti-schistosomiasis drugs is moving slowly,but pre-clinical and clinical trials found that combined medication of PZQ and various antimalarial drugs has shown good schistosomicidal effects.Also,synergistic effects have been exerted by combined use of PZQ and auxiliary drugs in the treatment of schistosomiasis.This article provides a review on the research progress in this field. |
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| Keywords: | Schistosomiasis Praziquantel Antimalarials Anti-fibrosis Antioxidants |
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