阿霉素肾病综合征大鼠肾内皮素变化及其影响的研究

目的观察内皮素对肾血流及蛋白尿的影响，探讨内皮素、肾血流在蛋白尿发生发展过程中的作用。方法制备大鼠阿霉素性肾病模型，动态观察不同病期大鼠血压、肾皮质血流、肾内皮素及24h尿蛋白量的变化，并将各指标进行相关分析。结果肾皮质内皮素升高发生在尿蛋白升高之前，随内皮素的升高，尿蛋白漏出量也随之增高，两者显著相关。内皮素可导致肾皮质血流的减少，在蛋白尿高峰期及高峰期后，减少的肾皮质血流可加重尿蛋白的发展，两者呈显著负相关。结论肾皮质ET的异常增加是导致蛋白尿发生的原因之一，肾血流量减少可加重蛋白尿的产生。

Experimental study on the effect of endothelin (ET) on renal blood flow and albuminuria in rats with Adriamycin Induced nephrotic syndrome

Objective To observe the influence of endothelin ET on renal b l ood flow and albuminuria and discuss the functions of endothelin ET and RBF during the formation and development of albuminuria. Methods Adriamycin nephrosis rat model was prepared and the renocorical blood flow and endothelin ET in different stages, the variations of the amount of albuminuria in 24 hours were observed . The results of relevant indexes were analyzed. Results There is a close relationship between endothelin and aIbuminuria. The level of endothelin increased before the increase of level of albuminuria and the amount of secretion of albuminura increased with the rising level of endothelin. Endothelin may reduce the renocortical blood flow. The result also showed the negative correlation between them as the reduced renocortical blood flow may strengthen the development of albuminuria after the level of albuminuria reached its peak. Conclusion The abnormal increase of endothelin ET is one of causes for formation of albuminuria and the reduction of renocortical blood flow may accelerate the development of the albuminuria.