| 心肌细胞凋亡的信号传导机制研究 |
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| 引用本文： | 许少峰,夏大胜. 心肌细胞凋亡的信号传导机制研究[J]. 中国心血管杂志, 2004, 9(3): 231-233 |
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| 作者姓名： | 许少峰 夏大胜 |
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| 作者单位： | 1. 南开大学医学院,天津,300071
2. 天津市第一中心医院心内科,天津,300192 |
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| 摘 要： | 细胞凋亡在心血管疾病发病机制中扮演了重要角色 ,细胞凋亡信号的异常表达使心肌细胞数量不断减少 ,其中含有 BH3( Bcl-2 Homology3 )结构域的凋亡促进分子 (如 Bax,Bid,BNIP3等 )在凋亡信号传导途径中发挥了重要作用。
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| 关 键 词： | 凋亡信号 心肌细胞 BH3结构域 信号传导途径 |
| 文章编号： | 1007-5410(2004)03-0231-03 |
| 修稿时间： | 2003-11-11 |
Research of signal transduction mechanism in apoptosis of cardiac myocytes |
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| XU Shao-feng ,XIA Da-sheng ..Medical College Of NanKai University,Tianjin ,China. Research of signal transduction mechanism in apoptosis of cardiac myocytes[J]. Chinese Journal of Cardiovascular Medicine, 2004, 9(3): 231-233 |
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| Authors: | XU Shao-feng XIA Da-sheng ..Medical College Of NanKai University Tianjin China |
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| Affiliation: | XU Shao-feng 1,XIA Da-sheng 2.1.Medical College Of NanKai University,Tianjin 300071,China, 2.The First Hospital of Tianjin,Tianjin 300192,China |
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| Abstract: | Apoptosis has played an important role in the mechanism of cardiovascular diseases. Abnormal expression of apoptotic signal made cardiac myocytes decreased irreverably. The proapoptotic proteins (Bax, Bid, BNIP3) which contain Bcl-2 Homology 3 domain (BH3) play an significaently role in the signal transduction pathway. |
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| Keywords: | Apoptotic signal Cardiac myocyte BH3 domain Signal transduction pathway |
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