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Association of I and II class HLA antigens with Cushing's syndrome] |
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| Authors: | A P Kalinin Iu M Zaretskaia A B Andrusenko V Iu Abramov E G Klinova O P Bogatyrev S I Donskov |
| Abstract: | Incidence of class I and II HLA antigens was studied in 69 patients suffering from Icenko--Cushing syndrome. Positive association was reported for antigens DRw53, DQw3, DR4, DR5, negative for antigen DR2. Antigen combinations DR5, DR7 and DR4, DR5 proved more prevalent. The risk to develop the disease rose 2-3-fold in case of HLA-DR5 phenotype occurrence with antigen DR4 or DR7. Association with DRw53 and DQw3 antigens showing wide specificity seemed most significant. |
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