| 用EXCEL考察不同厂家盐酸小檗碱片的溶出度 |
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| 引用本文： | 卢鹏伟,王梅香,牛艳阳.用EXCEL考察不同厂家盐酸小檗碱片的溶出度[J].河南大学学报(医学版),2006,25(2):28-30. |
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| 作者姓名： | 卢鹏伟 王梅香 牛艳阳 |
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| 作者单位： | 1. 河南大学,药学院,河南,开封,475001
2. 河大制药厂,河南,开封,475001 |
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| 摘 要： | 目的:考察不同厂家的盐酸小檗碱片的溶出度,为控制药品质量提供依据。方法:以水为溶出介质,按转篮法操作,用UV法检测,计算盐酸小檗碱片的相对累积溶出度,提取参数(T50,Td,m),并对参数进行相关性检验。结果:不同厂家、不同批号、不同包衣工艺的盐酸小檗碱片的溶出参数有极显著差异(P<0.01)。结论:生产厂家有必要优化制备工艺,来更好地控制药品质量。
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| 关 键 词： | 盐酸小檗碱片 溶出度 UV法 |
| 文章编号： | 1672-7606(2006)02-0028-03 |
| 收稿时间： | 2006-02-18 |
| 修稿时间： | 2006年2月18日 |
Study on the dissolution of Berberine Hydochloride Tablets produced by different factories with EXCEL |
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| LU Peng-wei,WANG Mei-xiang,NIU Yan-yang.Study on the dissolution of Berberine Hydochloride Tablets produced by different factories with EXCEL[J].Journal of Henan University,2006,25(2):28-30. |
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| Authors: | LU Peng-wei WANG Mei-xiang NIU Yan-yang |
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| Institution: | 1. Pharmaceutical College of Henan University, Kaifeng 475001, Henan, China; 2. Heda Pharmaceutical factory, Henan University, Kaifeng 475001, Henan, China |
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| Abstract: | Objective: TO determine the dissolution of berberine hydrochloride tablets produced by the different factories was determined in order to provide the basis for appraisal of the medicine quality.Methods: With Chinese Pharmacopoeia(2000) method 1-rotating busket method and using water as dissolution solution,UV spectrophotometry was adopted for the determination.The relative accumulative dissolution of berberine hydrochloride tablets was calculated.The parameters(T_(50),T_(d),m) extracted from these samples were processed for correlation test.Results: The dissolution parameters of berberine hydrochloride tablets from the different factories,the different batches and the different coated tablets were remarkably different(P<0.01).Conclusion: It is necessary to better the technology of preparation to control the medicine quality. |
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| Keywords: | berberine hydrochloride tablets dissolution UV spectrophotometry |
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