氯吡格雷治疗不稳定心绞痛疗效分析及安全性评价

目的：观察不稳定型心绞痛患者应用氯吡格雷进行治疗的临床疗效及不良反应发生情况。方法：选取不稳定型心绞痛患者86例，随机分成两组，对照组（ n＝43）：予以传统治疗；观察组（ n＝43）：在对照组治疗的基础上给予氯吡格雷治疗。结果：两组患者治疗前的C反应蛋白、血粘度情况、心绞痛的发作频率、持续时间及日消耗硝酸甘油量比较，均无统计学意义（ P＞0．05）；治疗后两组患者的C反应蛋白、血粘度情况、心绞痛的发作频率、持续时间及日消耗硝酸甘油量组间及组内比较，均有统计学意义（ P﹤0．05）；观察组总有效率为88．73％，对照组总有效率为74．42％，比较具有显著的统计学意义（ P＜0．05）；两组患者的安全性比较，具有统计学意义（ P＜0．05）。结论：对不稳定型心绞痛患者应用氯吡格雷具有安全、显著的临床疗效，适合在临床上广泛推广应用。

Efficacy and Safety of Clopidogrel in Treatment of Patients with Unstable Angina Pectoris

Objective：To observe the clinical efficacy and adverse reactions of clopidogrel in treatment＆amp;nbsp;of patients with unstable angina .Method：86 cases of unstable angina patients , randomly divided into two groups, the control group （n=43）：to be the traditional treatment; the observation group （n=43）： clopi-dogrel therapy based on the treatment in control group .Result：Before treatment , C reactive protein , blood viscosity , angina attack frequency , duration and daily consumption of nitroglycerin quantity in patients of two groups were compared, There＆#39;s no statistical significance difference （P＆gt;0.05）;After treatment ,C reactive protein,blood viscosity , angina attack frequency , duration and daily consumption of nitroglycerin was com-pared between two groups , there was statistically significant difference （ P ＆lt;0.05）;Total effective rate was 88.73%and 74.42%in the observation group and control group , There＆#39;s statistically significant difference （P＆lt;0.05）.Conclusion：The effect is safe, significant on unstable angina with clopidogrel ,It＆#39;s suitable for wide application in clinical practice .