环磷腺苷葡胺联合维生素C治疗新生儿窒息后心肌损伤的疗效及对CK和CK-MB水平的影响

目的：探讨环磷腺苷葡胺联合维生素C在新生儿窒息后心肌损伤治疗中的临床疗效。方法：选择2011年1月至2013年6月我院收治的新生儿窒息后心肌损伤患儿56例，随机分为观察组和对照组，每组各28例。对照组给予常规治疗，观察组在常规治疗的基础上加用环磷腺苷葡胺和维生素C 静脉滴注。比较分析两组治疗效果。结果：观察组的治疗有效率优于对照组（ P＜0．05）；治疗14d后观察组患儿血清中CK与CK-MB含量均低于对照组（ P＜0．05）。结论：将环磷腺苷葡胺与维生素C联合应用在新生儿窒息后心肌损伤的临床治疗中，高效安全、无副作用，值得临床进一步推广与应用。

The Clinical Efficacy of Meglumine Adenosine Cyclophosphate and Vitamin C in the Treatment of Myocardial Injury after Neonatal Asphyxia

Objective：To study the clinical efficacy of meglumine adenosine cyclophosphate and vitamin C in the treatment of myocardial injury after neonatal asphyxia .Method：The clinical data of 56 patients with neonatal asphyxia after myocardial damage was analyzed retrospectively .They were randomly divided into the treatment group （28 cases） and the control group （28 cases）.The control group received conventional therapy treatment , and the treatment group was given with meglumine adenosine cyclophosphate and vitamin C intravenous infusion on the basis of the conventional treatment .The clinical efficacy , serum creatine kinase and creatine kinase isoenzyme levels for the two groups after treatment were observed .Result： After treatment , the total effective rate of the treatment group was significantly higher than that of control group .The serum CK, creatine kinase isoenzyme CK-MB content after treatment reduced than before treatment. The serum CK, CK-MB levels in the treatment group were significantly was lower than the control group .Conclusion：The clinical efficacy for meglumine adenosine cyclophosphate combined with Vitamin C in the treatment of myocardial injury after neonatal asphyxia is significant .