硝苯地平联合硫酸镁治疗妊娠期高血压疾病安全性临床疗效探讨

目的：探究并分析硝苯地平联合硫酸镁治疗妊娠期高血压疾病孕妇临床疗效和安全性。方法：选择我院2011年2月至2012年12月收治的96例妊娠期高血压疾病孕妇为研究对象,应用随机数字表法将妊娠期高血压疾病孕妇分为对照组和实验组,各48例,对照组孕妇接受静脉滴注硫酸镁治疗;实验组孕妇接受静脉滴注硫酸镁和口服硝苯地平控释片治疗,采用t检验和X2检验比较两组孕妇临床疗效、收缩压、舒张压、随机尿白蛋白肌酐比值、24h尿蛋白定量、血黏度、血细胞压积、胎儿脐动脉收缩压与舒张压的比值等临床指标。结果：对照组孕妇治疗总有效率为89.58%（43/48）,实验组总有效率为97.92%（47/48）,实验组孕妇治疗总有效率明显高于对照组,差异具有统计学意义（P〈0.05）,治疗后,孕妇收缩压（121.49±13.86）mmHg、舒张压（81.16±5.97）mmHg、随机尿白蛋白肌酐比值（121.85±98.02）mg/mmoL、24h尿蛋白定量（1.22±0.94）g/24h、血黏度（2.01±0.85）mPa、血细胞压积（31.75±1.23）%、胎儿脐动脉收缩压与舒张压的比值（1.67±0.31）,各指标显著低于对照组,差异具有统计学意义（P〈0.05）。结论：硝苯地平联合硫酸镁治疗妊娠期高血压疾病临床疗效确切,具有安全高效和不良反应少等特点。

Clinical Efficacy and Safety of Pregnant Women with Gestational Hypertension Disease Treated by Nifedipine Combined Magnesium Sulfate

Objective： To evaluate the clinical efficacy and safety of pregnant women with gestational hypertension disease treated by nifedipine combined magnesium sulfate. Method： Ninety- six pregnant women with gestational hypertension disease who were treated in our hospital from Feb. 2011 to Dec. 2012were chosen as the research objects,they were divided into the control group（ cases = 48） and the experimental group（ cases = 48） by random number table.The patients in the control group were given magnesium sulfate by intravenous drip,the patients in the experimental group were given magnesium sulfate combined oral nifedipine intravenous drip. Clinical efficacy of pregnant women,systolic pressure,diastolic blood pressure,and random urine albumin creatinine ratio,24-hour urine protein,blood viscosity,haematocrit,quantitative the ratio of fetal umbilical artery systolic blood pressure and diastolic blood pressure of two groups were compared by T test and chi-square test. Result： The total effective rate of pregnant women was 89.58%（ 43 /48）and 97.92%（ 47 /48） in the control group and experimental group.The total effective rate in the experimental group was higher than that in the the control group（ P＆lt;0.05）.After treatment,pregnant women systolic blood pressure was（ 121.49±13.86 mmHg）,diastolic blood pressure was（ 81.16±5.97） mmHg,random urine albumin creatinine ratio was（ 121.85±98.02） mg / mmoL,24 hours urinary protein quantitative was（ 1.22±0.94） g /24h,blood viscosity was（ 2.01±0.85） mPa,haematocrit was（ 31.75±1.23） %,the ratio of fetal umbilical artery systolic blood pressure and diastolic blood pressure was（ 1.67±0.31）.The index in the experimental group was significantly lower than those in the control group（ P＆lt;0.05）. Conclusion： The clinical efficacy and safety of pregnant women with gestational hypertension disease by nifedipine combined magnesium sulfate is definite,it is safe and effective and with less adverse reactions.