子痫前期患者血清炎性因子水平变化和铁蛋白的临床意义

目的：探讨子痫前期患者血清炎性因子C-反应蛋白（ CRP ）、肿瘤坏死因子α（ TNF-α）、γ干扰素（ IFN-γ）水平变化和血清铁蛋白（ SF）水平的临床意义。方法：ELISA法检测血清CRP、TNF-α、IFN-γ和血清铁蛋白在53例轻度子痫和47例重度子痫前期及100例正常孕妇中的水平。结果：正常妊娠孕妇的CRP、TNF-α、IFN-γ水平与子痫前期患者比较差异有统计学意义（ P＜0．05）；重度子痫前期组的CRP、TNF-α、IFN-γ水平与轻度子痫前期组比较差异有统计学意义（ P＜0．05）；三者随病情的加重逐渐升高。各组间血清铁蛋白水平差异均无统计学意义（ P＞0．05）。结论：CRP、TNF-α、IFN-γ参与子痫前期的发生及发展，可作为其进展性的预测指标。

Serum Levels of Inflammatory Factors and the Expression of Serum Ferritin in Patients with Preeclampsia

Objective： To investigate the clinical changes and significance of the levels of inflammatoryfactor serum C-reactive protein （CRP）, tumor necrosis factor-α（TNF-α）, interferon-γ（IFN-γ） and serumferritin（SF） in patients with preeclampsia.Method： Serum CRP, TNF-α, IFN-γand SF levels weremeasured by using radioim-munoassay in 53 mild pre-eclampsia patients,47 severe pre-eclampsia patients,and 100 normal pregnant women.Result： There were significant difference in CRP, TNF-αand IFN-γbetweennormal patients and preeclampsia patients （P＆lt;0.05）, and there were significant difference in CRP ,TNF-αand IFN-γbetween mild preeclampsia patients and severe ones （P ＆lt;0.05）.The levels of CRP, TNF-αand IFN-γgradually elevated with the increasing of seveirty of disease .There was no significant differencein SF between different groups （P ＆gt;0.05）.Conclusion： CRP, TNF-α, IFN-γinvolved in the occurrenceand development of pre-eclampsia,It can be used as predictors of the progress.