血清 IL-23联合血浆脑钠肽检测对判断慢性心力衰竭患者预后的影响 |
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引用本文: | 王志贵,范艺花.血清 IL-23联合血浆脑钠肽检测对判断慢性心力衰竭患者预后的影响[J].河北医学,2014,0(10):1601-1604. |
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作者姓名: | 王志贵 范艺花 |
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作者单位: | 王志贵 (陕西省汉中市汉江职工医院,陕西 汉中,723003); 范艺花(陕西理工学 院,陕西 汉中,723001); |
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基金项目: | 陕西省自然科学基金项目,(项目编号:编号2011SM55) |
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摘 要: | 目的:探究分析血清IL-23联合血浆脑钠肽检测对判断慢性心力衰竭患者预后的指标及影响。方法:选取我院自2011年5月至2013年5月收治的慢性心力衰竭患者51例,作为临床研究对象,作为试验组。选取同期51名健康体检者,作为对照组。检测试验组患者与对照组健康人血清IL-23、血浆脑钠肽含量,并比较它们的阳性检测率。结果:试验组患者血清IL-23、血浆脑钠肽阳性检出率(96.08%、94.12%)高于对照组(7.84%、9.80%),P<0.05;试验组患者51例中心功能改善及心衰在住院患者即存活患者共48例,BNP 水平与YNHA分级之间呈正相关且差异明显( P<0.05),BNP 水平升高患者的死亡率也随之增加。结论:血清IL-23联合血浆脑钠肽检测对判断慢性心力衰竭患者预后有一定优势,其变化能能反映出慢性心衰患者的心脏功能分级情况及病情进展,更准确地判断预后,对患者病情的评价具有一定的意义,值得临床推广使用。
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关 键 词: | 血清IL-23 血浆脑钠肽 慢性心力衰竭 预后 Serum IL-23 |
Influence of Serum IL-23 Combined with Plasma Brain Natriuretic Peptide on Judging the Prognosis of Patients with CHF |
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Institution: | WANG Zhigui, et al ( Hanjiang Worker's Hospital of Hanzhong, Shanxi Hanzhong 723003, China ) |
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Abstract: | Objective:To explore the influence of serum IL-23 combined with plasma brain natriuretic peptide on judging the prognosis indicators of patients with chronic heart failure ( CHF) .Method:51 patients with CHF treated in our hospital from May 2011 to May 2013 were selected as the clinical research object , as the experimental group .And selected 51 healthy subjects as control group in the same period .Detected the content of serum IL-23 and plasma brain natriuretic peptide in the two groups and compared the positive de-tection rate.Result:The possitive detection rate of serum IL-23 and plasma brain natriuretic peptide of ex-perimental group (96.08%,94.12%) were significantly higher than those in control group (7.84%,9.80%) (P〈0.05);In experimental group (51 cases),there were 48 patients had their cardiac function improved and survived ,BNP level had positive correlation with YNHA grading , difference was significant ( p〈0.05 ) , and mortality increased when BNP level increased .Conclusion:Serum IL-23 combined with plasma brain natri-uretic peptide has certain advantages in judging the prognosis of patients with CHF , which can reflect cardiac function classfication and progressive disease and more accurate ,have certain significance in evaluating path-ogenetic condition of the patients , it’ s worthy of being applied in clinic . |
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Keywords: | Plasma brain natriuretic peptide Chronic heart failure Prognosis |
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