PTEN 与 p53在鼻咽癌中的表达及意义

目的：探讨PTEN基因缺失和p53基因突变在鼻咽癌中的表达及临床意义。方法：本实验以50例鼻咽癌标本作为病例组，以50例正常子鼻咽部组织作为对照组，应用免疫组织化学技术检测二组中PTEN和p53的表达，分析其不同临床病理特征中的意义及对预后的判断价值。结果：病例组PTEN阴性24例，对照组阴性0例，两组比较差异有显著的统计学意义（P＜0．01），Ⅲ期和Ⅳ期以及有淋巴结转移的患者PTEN 阴性比例明显高于PTEN 阳性患者，差异有有显著的统计学意义（ P＜0．01），病例组PTEN阳性38例，对照组阳性22例，两组比较差异有显著的统计学意义（P＜0．01），有淋巴结转移的患者p53阳性比例明显高于p53阴性患者，差异有有显著的统计学意义（ P＜0．01）。结论：PTEN基因缺失和p53基因突变与鼻咽癌发生和发展密切相关。

Expression and Clinical Significance of PTEN Gene and p53 Gene in Nasopharyngeal Carcinoma

Objective：To study clinical significance of deletion of PTEN gene and mutation of p 53 gene in nasopharyngeal carcinoma .Method： 50 cases with nasopharyngeal carcinoma were collected as case group,50 cases with normal nasopharyngeal as control group .and then analyzed the expressions of PTEN and p53 in the two groups by immunohistochemisty .The different clinical characteristic were analyzed .Result：PTEN deletion in 24 cases in case group , None of cases in PTEN deletion in control group , the difference was significant statistical significance （ P〈0.01 ） .Ⅲ and Ⅳ and lymph node metastasis was significantly higher than the proportion in PTEN-negative higher than PTEN-positive patients , There＇s a significant difference （P〈0.01）, PTEN-positive was 38 cases in case group, 22 cases of positive control group, the difference was significant statistical significance （ P〈0.01） , lymph node metastasis p 53 in positive-negative patients were higher than p53-negative patients,There＇s a significant difference （P〈0.01）.Conclusion：Deletion of PTEN gene and mutation of p 53 gene correlation with carcinogenesis and progression in nasopha-ryngeal carcinoma .