The short arm of chromosome 6 is nonrandomly rearranged in secondary myelodysplastic syndromes |
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Authors: | C Mecucci J L Michaux A Louwagie M Boogaerts H Van den Berghe |
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Affiliation: | Center for Human Genetics, University of Leuven, Belgium. |
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Abstract: | Eight patients with a myelodysplastic syndrome showed a structural rearrangement of the short arm of chromosome #6 involving the distal segment 6p22----6pter. In four cases the myelodysplastic disorder appeared after treatment with chemo- and/or radiotherapy. Cytogenetically, the 6p anomaly was consistently associated with abnormalities of chromosome #5 and/or #7 in seven of eight cases. We believe we identified a new site on 6p that is nonrandomly involved in iatrogenically and possibly also environmentally induced malignant hematologic disorders. |
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