丹芎抑凝饮对心脏瓣膜置换术后抗凝的实验研究

目的观察丹芎抑凝饮对家兔内源性、外源性凝血途径、优球蛋白溶解时间及血小板最大聚集率的影响。方法将家兔24只随机分为4组,即空白对照组、华法林组、丹芎抑凝饮高剂量组、丹芎抑凝饮低剂量组。各组按kg体重灌胃给药。定时抽血测定凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和优球蛋白溶解时间、血小板最大聚集率。结果服药第5日丹芎抑凝饮低、高剂量组、华法林组与空白对照组比较PT、APTT均显著延长(P<0.05)。丹芎抑凝饮低、高剂量组与华法林组无统计学差异(P>0.05)。丹芎抑凝饮低、高剂量组优球蛋白的溶解时间(ELT)和血小板最大聚集率与空白对照组比较显著降低(P<0.01)。结论丹芎抑凝饮可使PT、APTT显著延长,对凝血过程中存在的内源性和外源性途径都存在干预作用。并能够显著抑制血小板的聚集,在某些方面可以替代华法林。

Experimental research of Danxiongyiningyin on anticoagulant of cardiac valve replacement

Objective To research influence of Danxiongyiningyin on endogenous,extrinsic coagulation and hemorheology in rabbit.Methods 24 rabbits were randomly divided into 4 groups.They were control group,Warfarin group,low-dose Danxiongyiningyin group and high-dose Danxiongyiningyin group.PT,APTT,whole blood viscosity,plasma viscosity,erythrocyte aggregation and erythrocyte deformability were observed in four groups.Results PT,APTT in low-dose Danxiongyiningyin group,high-dose Danxiongyiningyin group and Warfarin group were longer than those in control group 5 days after administration(P<0.05).There were no significant differences between Warfarin group and low-dose Danxiongyiningyin group,high-dose Danxiongyiningyin group(P>0.05).Improvement of hemorheology index in low-dose Danxiongyiningyin group,high-dose Danxiongyiningyin group was superior to those in Warfarin group(P<0.05).The results were observed in whole blood viscosity,plasma viscosity,erythrocyte aggregation and erythrocyte deformability.Conclusion Danxiongyiningyin can prolong PT,APTT and influence endogenous,extrinsic coagulation.It can improve indexes of hemorheology.