舌鳞癌组织中Cyclin D1的表达与临床病理相关性

目的: 探讨细胞周期素D1(Cyclin D1)在舌癌中的表达及临床病理相关性. 方法: 采用免疫组化ABC法检测42例舌鳞状细胞癌、19例良性肿瘤石蜡包埋标本的Cyclin D1表达. 结果: Cyclin D1在舌癌细胞核中呈阳性表达,阳性表达率55%,与组织学分级及淋巴结转移呈明显正相关(r=0.388, P<0.05). 生存分析资料显示Cyclin D1( )、(-)两组5 a相对复发危险度(RRR) u=1.959(P>0.05),Kaplan-Meier生存曲线示两组5 a累积无复发生存期(RFS)无显著差异(P>0.05). 结论: Cyclin D1在舌癌中异常表达,其表达可能与肿瘤分化及发展相关,Cyclin D1的表达与预后无关.

Expression and clinicopathologic significance of Cyclin D1 in squamous cell carcinoma of tongue

AIM: To study the expression and clinicopathologic relation of Cyclin D1 in tongue squamous cell carcinoma. METHODS: Paraffin embedded archival materials from 42 cases of tongue squamous cell carcinoma and 19 cases of benign disease were examined for the expression of Cyclin D1 with immunohistochemistry by retrospective study. RESULTS: Overexpression of Cyclin D1 in nucleus was found in 55% cases of tongue squamous cell carcinoma, and in direct proportion to histopathologic grading and lymphoid node metastasis ( P <0.05). To compare Cyclin D1 positive with negative group, the recurrence relative risk (RRR) is 1.959 ( P >0.05) and the recurrence free survival (RFS) is not significant in Kaplan Meier Surival curve ( P >0.05). CONCLUSION: Overexpression of Cyclin D1 was found in tongue squamous cell carcinoma tissue. It may be correlated with the development and differentiation of the tumor, but its expression cannot be acted as a prognostic marker.