| 阿普唑仑口腔崩解片的制备及质量评价 |
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| 引用本文： | 毛叶萌,张奇志,钱景时,沈洁净,李琦,蒋新国.阿普唑仑口腔崩解片的制备及质量评价[J].中国药学杂志,2009,44(1):36-39. |
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| 作者姓名： | 毛叶萌 张奇志 钱景时 沈洁净 李琦 蒋新国 |
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| 作者单位： | 1.复旦大学药学院药剂学教研室 上海 200032;2.上海市精神卫生中心 上海 200030;3.上海中医药大学 上海 201203 |
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| 基金项目： | 上海市卫生局资助项目(2006065) |
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| 摘 要： | 目的制备阿普唑仑口腔崩解片,并评价其质量。方法直接粉末压片法制备口腔崩解片。以片剂崩解时限、口感为指标,采用正交实验设计优化处方。结果所得片剂完整光洁,口感良好,能在30 s内崩解完全,2 min内溶出百分率>90%。结论阿普唑仑口腔崩解片达到了设计要求,能方便患者服药。
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| 关 键 词： | 阿普唑仑 口腔崩解片 正交实验 处方工艺 质量评价 |
| 收稿时间： | 2008-05-19; |
Preparation and Quality Control of Alprazolam Orally Disintegrating Tablet |
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| MAO Ye-meng,ZHANG Qi-zhi,QIAN Jing-shi,SHEN Jie-jing,LI Qi,JIANG Xin-guo.Preparation and Quality Control of Alprazolam Orally Disintegrating Tablet[J].Chinese Pharmaceutical Journal,2009,44(1):36-39. |
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| Authors: | MAO Ye-meng ZHANG Qi-zhi QIAN Jing-shi SHEN Jie-jing LI Qi JIANG Xin-guo |
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| Institution: | 1. Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China; 2. Shanghai Mental Health Center, Shanghai 200030, China; 3. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | OBJECTIVE To prepare orally disintegrating tablets containing alprazolam and investigate its quality.METHODS The tablets was prepared using the direct compression method.The formulation was optimized with disintegration time and taste as reference parameters by an orthogonal design.RESULTS The orally disintegrating tablets were integrity and smooth with desirable taste and feel in the mouth.The disintegration time was less than 30 s,and the cumulative dissolution percentage was higher than 90% within 2 min.CONCLUSION The orally disintegrating tablets developed in this work will hopefully contribute to improve drug administration to patients. |
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| Keywords: | alprazolam orally disintegrating tablet orthogonal design formulation quality contol |
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