动态增强磁共振成像定量参数对子宫肌瘤高强度聚焦超声治疗效果的即时评估价值初探

目的通过研究子宫肌瘤动态增强磁共振成像(dynamic contrast-enhanced MRI,DCE-MRI)定量参数与治疗效果的相关性,探讨定量参数对子宫肌瘤高强度聚焦超声(high intensity focused ultrasound,HIFU)治疗效果即时评估的应用价值。材料与方法回顾分析子宫肌瘤HIFU治疗的13个病例,根据治疗后DCE-MRI表现分为完全消融组及不完全消融组。应用Mann-Whitney U秩和检验和Spearman秩相关分析研究定量参数与分组的关联。结果 Ktrans(治疗后)、Ve(治疗后)、Vp(治疗后)与分组呈正相关,相关系数分别为r=0.713、0.757和0.668;Ktrans(变化率)、Ve(变化率)与分组呈负相关,相关系数均为r=-0.802,且相关性更显著。结论 DCE-MRI定量参数对子宫肌瘤HIFU治疗疗效即时评估具有参考价值。

The preliminary value of DCE-MRI quantitative parameters in high intensity focused ultrasound (HIFU) ablation's immediate effect for uterine ifbroids

AbstractObjective:To evaluate the immediate value of dynamic contrast-enhanced MRI(DCE-MRI)quantitative parameters after HIFU treatment of uterine fibroids. Materials and Methods:Thirteen patients with uterine fibroids were scanned with DCE-MRI before and after HIFU ablation. They were grouped into two groups, the complete ablation group and the non-complete ablation group according to appearance of DCE-MRI.Mann-Whitney U test andSpearman's correlations were applied to ifnd the association between quantitative parameters and grouping.Results:Ktrans(after treatment), Ve (after treatment) and Vp (after treatment) were positively correlated with the grouping, and correlation coefifcents were 0.713 , 0.757 and 0.668 respectively. Ktrans(rate of change)and Ve (rate of change) were negatively correlated with the grouping,and correlation coefifcients were both -0.802.Conclusion:DCE-MRI quantitative parameters have reference value in HIFU treatment's immediate effect evaluations for uterine ifbroids.