盐酸左氧氟沙星治疗难治性肺结核的临床疗效和安全性汇总分析

目的考察盐酸左氧氟沙星对难治性肺结核的临床疗效和安全性,为该类疾病的临床治疗提供参考。方法以我科2007年5月—2013年7月间收治的106例难治性肺结核患者为研究对象,将其随机分为对照组和治疗组。对照组给予对氨基水杨酸异烟肼、吡嗪酰胺等药物,治疗组加用盐酸左氧氟沙星治疗。随后评价两组患者的临床疗效和不良反应发生情况。结果治疗组和对照组患者的转阴率分别为79.24%和58.49%,病灶、空洞明显吸收率和总吸收率分别为（85.94%Vs 71.70%）和（45.28%Vs 25.53%）,两组相比差异具有统计学意义（P〈0.05）。在不良反应方面,治疗组的不良反应总发生率高于对照组,且组间差异具有统计学意义（P〈0.05）。结论盐酸左氧氟沙星对难治性结核有明确的临床疗效,值得临床推广使用。

The meta-analysis about the clinical efficacy and safety of levofloxacin for the treatment of the refractory tuberculosis

Objective To investigate the clinical efficacy and safety of quinolones for the treatment of the refractory tuberculosis,order to provide a clinical reference for the treatment of refractory tuberculosis. Methods 106 cases patients with vwhich were treated in our hospital during 2007.05-2013.07, and were randomly divided into treated group and control group, the control group was treated with pyrazinamide, isoniazid. etc., and the treated group was treated with levofloxacin based on the original prorgram.Then evaluated the clinical effect and incidence of the adverse reactions of the groups. Results The negative rate of treated group and control group was 79.24% and 58.49% respectively, the absorption rate of the lesion cavity obvious and total absorption rate was（85.94%Vs 71.70%） and（45.28% Vs 25.53%）, and the difference between the two groups was statistically significant（P〈0. 05）. In the aspect of adverse reactions, the incidence of the adverse reactions of treated group was lower than the control group,and the difference was statistically significant（P〈0. 05）. Conclusion Levofloxacin has a clear clinical efficacy for the refractory tuberculosis, worthy of clinical application.