Typing of Human Mycobacterium avium Isolates in Italy by IS1245-Based Restriction Fragment Length Polymorphism Analysis |
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| Authors: | Nicoletta Lari Michela Cavallini Laura Rindi Elisabetta Iona Lanfranco Fattorini and Carlo Garzelli |
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| Institution: | Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, Università di Pisa, I-56127 Pisa,1. and Laboratory of Bacteriology and Medical Micology, Istituto Superiore di Sanità, I-00161 Rome,2. Italy |
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| Abstract: | All but 2 of 63 Mycobacterium avium isolates from distinct geographic areas of Italy exhibited markedly polymorphic, multibanded IS1245 restriction fragment length polymorphism (RFLP) patterns; 2 isolates showed the low-number banding pattern typical of bird isolates. By computer analysis, 41 distinct IS1245 patterns and 10 clusters of essentially identical strains were detected; 40% of the 63 isolates showed genetic relatedness, suggesting the existence of a predominant AIDS-associated IS1245 RFLP pattern. |
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