| 雌激素受体与骨性关节炎 |
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| 引用本文： | 高峰,杜宁.雌激素受体与骨性关节炎[J].医学综述,2008,14(1):33-35. |
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| 作者姓名： | 高峰 杜宁 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院伤科,上海市伤骨科研究所,上海,200025 |
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| 摘 要： | 雌激素受体在正常及关节炎关节软骨中均有表达,其基因多态性引起的蛋白活性及构象差异可能引起雌激素对关节软骨的作用差异。绝经后雌激素水平下降,女性骨性关节炎发病率较男性明显增加。雌激素替代疗法可能降低绝经后妇女骨关节炎发病率改善关节炎症状。现就目前有关雌激素及其受体对骨关节炎影响方面的研究进展进行综述,探讨雌激素及其受体与骨性关节炎之间的关系。
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| 关 键 词： | 骨性关节炎 雌激素受体 雌激素 |
| 文章编号： | 1006-2084（2008）01-0033-03 |
| 收稿时间： | 2007-06-16 |
| 修稿时间： | 2007-12-09 |
Estrogen Receptor and Osteoarthritis |
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| GAO Feng,DU Ning.Estrogen Receptor and Osteoarthritis[J].Medical Recapitulate,2008,14(1):33-35. |
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| Authors: | GAO Feng DU Ning |
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| Institution: | GAO Feng,DU Ning.(Department of Traumatology , Ruijin Hospital Affiliated to Medical College of Shanghai Jiao Tong University, Institute of Osteotrauma in Shang-hai, Shanghai 200025, China) |
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| Abstract: | The estrogen receptors(ER)has expression in arthrodial cartilage of normal articles and arthritis.The protein activity and conformation difference resulting from gene polymorphismcan often result in the different effect of estrogen on arthrodial cartilage.The incidence rate of osteoarthritis in female is higher than that of male because of decreased estrogen level during post-menopause.Estrogen substitution therapy can decrease the incidence rate of osteoarthritis in post-menopause females and improve their symptom.This article reviews progresses about the effect of estrogen and its receptor on osteoarthritis in order to debate the relationship of estrogen and its receptor with osteoarthritis. |
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| Keywords: | Osteoarthritis Estrogen receptor Estrogen |
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