The analgesic efficacy of pregabalin for shoulder arthroscopy: A meta-analysis of randomized controlled trials |
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| Authors: | Chunhong Liu Ling Cheng Bo Du Shuang Cheng Yangming Jiang Xiaohong Tan Ke Qian |
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| Institution: | aDepartment of Anesthesiology, People''s Hospital of Chongqing Banan District;bDepartment of Hepatological Surgery, The People''s Hospital of Kaizhou District, Chongqing, China;cDepartment of Surgery, The TCM Hospital of Kaizhou District, Chongqing, China. |
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| Abstract: | Introduction:The efficacy of pregabalin for pain management of shoulder arthroscopy remains controversial. We conduct this meta-analysis to explore the influence of pregabalin versus placebo on the postoperative pain intensity of shoulder arthroscopy.Methods:We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through November 2019 for randomized controlled trials assessing the effect of pregabalin versus placebo on pain control of shoulder arthroscopy. This meta-analysis was performed using the random-effect model.Results:Three randomized controlled trials were included in the meta-analysis. Overall, compared with control group for shoulder arthroscopy, pregabalin remarkably decreased pain scores at 0 to 1 hour (Std. MD = −0.57; 95% CI = −1.04 to −0.09; P = .02) and 12 hours (Std. MD = −0.37; 95% CI = −0.72 to −0.02; P = .04), as well as analgesic consumption (Std. MD = −1.84; 95% CI = −2.24 to −1.44; P < .00001), but showed no notable influence on pain scores at 24 hours (Std. MD = −0.54; 95% CI = −1.47 to 0.38; P = .25), nausea or vomiting (RR = 0.84; 95% CI = 0.53–1.33; P = .45), dizziness (RR = 1.14; 95% CI = 0.89–1.47; P = .30).Conclusions:Pregabalin may benefit to pain control after shoulder arthroscopy. |
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| Keywords: | meta-analysis pain management pregabalin randomized controlled trials shoulder arthroscopy |
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