域发微针联合红光治疗雄激素性脱发的临床疗效分析

目的 观察域发微针联合红光治疗雄激素性脱发（AGA）的临床疗效。方法 选取2021年1月—2022年6月西南医科大学附属医院皮肤科就诊的90例AGA患者，随机分为微针组（域发微针治疗）、红光组（红光治疗）、联合组（域发微针联合红光治疗），每组30例。比较各组治疗前后主观症状评分、毛发镜指标；比较各组临床疗效、患者满意度及不良反应。结果 联合组治疗前后油腻、瘙痒、头屑、脱发评分差值的变化程度均高于微针组、红光组（P <0.05）。联合组治疗前后毳毛比例、毛发密度、毛干直径差值的变化程度均高于微针组、红光组（P <0.05）。联合组总有效率、满意度高于微针组、红光组（P <0.0125）。各组脂溢性皮炎、头皮瘙痒、头屑增加、头皮感染、耳后淋巴结肿大、湿疹发生率比较，差异均无统计学意义（P>0.05）。结论域发微针及红光联合治疗AGA可有效改善患者症状，提高临床疗效及满意度，促进毛发生长，增加毛发密度、毛干直径，且安全可靠。

Clinical efficacy of Yufa microneedling combined with red light therapy for androgenic alopecia

Objective To observe the clinical efficacy of Yufa microneedling combined with red light therapy for androgenetic alopecia (AGA).Methods Ninety patients with AGA who visited the Department of Dermatology of the Affiliated Hospital of Southwest Medical University from January 2021 to June 2022 were enrolled and randomly divided into microneedling group (Yufa microneedling therapy), red light group (red light therapy), and combination group (Yufa microneedling combined with red light therapy), with 30 cases in each group. The subjective symptom scores and trichoscopy findings before and after treatment were compared among the three groups. The clinical efficacy, patient satisfaction, and adverse reactions were also compared among the three groups.Results The differences of the scores in terms of greasiness, itching, dandruff, and hair loss before and after treatment in the combination group were higher than those in the microneedling group and the red light group (P < 0.05). The differences of the percentage of vellus hair, hair density, and hair shaft diameter before and after treatment in the combination group were higher than those in the microneedling group and the red light group (P < 0.05). The overall effective rate and satisfaction rate in the combination group were higher than those in the microneedling group and the red light group (P < 0.05). The incidences of seborrheic dermatitis, itching scalp, increased dandruff, scalp infection, enlarged lymphonodi retroauriculares, and eczema were not different among the three groups (P > 0.05).Conclusion Yufa microneedling combined with red light therapy is effective for treating AGA by improving the symptoms, clinical efficacy, and satisfaction of patients, promoting hair growth, and increasing hair density and hair shaft diameter, and is safe and reliable.