| J—911对实验性肝损伤的保护作用 |
| |
| 引用本文： | 曾伟 王菊英. J—911对实验性肝损伤的保护作用[J]. 中国海洋药物, 1999, 18(3): 26-29 |
| |
| 作者姓名： | 曾伟 王菊英 |
| |
| 作者单位： | 山东医科大学基础医学院药理教研室!济南250012 |
| |
| 摘 要： | 通过建立小鼠急性肝损伤及大鼠慢性肝损伤模型，观察并研究海洋药物Ｊ－９１１对小鼠急性肝损伤及大鼠慢性肝损伤的保护作用。结果表明，Ｊ－９１１能明显降低Ｄ－半乳糖胺引起急性肝损伤疡血清ＡＬＴ升高和四氯化碳引起的急性肝损伤小鼠的血清ＡＬＴ、ＡＳＴ的升高，明显减轻模型肝组织病理损伤。
|
| 关 键 词： | J－911 肝损伤 肝纤维化 动物实验 |
THE PROTECTIVE EFFECTS OF J-911 ON EXPERIMENTAL LIVER INJURY |
| |
| Cao Wei,Wang Juying,Ma Jianfeng,Yuan Wei. THE PROTECTIVE EFFECTS OF J-911 ON EXPERIMENTAL LIVER INJURY[J]. Chinese Journal of Marine Drugs, 1999, 18(3): 26-29 |
| |
| Authors: | Cao Wei Wang Juying Ma Jianfeng Yuan Wei |
| |
| Abstract: | The projective effects of J - 911 on the acute liver injury in mice and the chronic liver in jury in rats were observed and studied by establishing animal models. The results showed that J - 911 sig nificantly decreased the elevation of serum ALT induced by Galn and the elevation of serum ALT. J - 911 markedly decreased the elevation of serum AST. ALT and hydroxyproline in liver tissue of hepatic fibrosis rats induced by ccl_4, the liver tissue injuries of hepatic fibrosis rats were also ameliorated. The results sug gest that J - 911 may have protective effects on experimental liver injury. |
| |
| Keywords: | J - 911 Ccl_4 D - galactosamine acute liver injury hepatic fibrosis |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中国海洋药物》浏览原始摘要信息 |
|
点击此处可从《中国海洋药物》下载全文 |
