骨基质明胶与羟基磷灰石修复兔桡骨缺损模型的对照研究

目的比较骨基质明胶(BMG)与羟基磷灰石(HAC)在节段性骨缺损愈合上的差别。方法把16只新西兰大白兔的双侧桡骨制造成10m的骨缺损模型，分别植入BMG、自体骨段和HAC及旷置。在术后即刻，2、4和8周进行放射学、组织学、扫描电镜和骨密度的检测。结果发现BMG组术后4周即有新骨形成，8周缺损已愈合；组织学发现植入BMG的缺损处为多中心成骨，术后8周已基本吸收，而植入HAC的骨缺损处也可见到缺损愈合，但HAC没有降解。结论治疗兔桡骨缺损模型上，BMG和自体骨有相近的疗效，并优于在体内吸收较差的HAC。

Study of the Bone Matrix Gelatin and Hydroxyapatite Cement for Repair of the Radius Segmental Defect of Rabbits

Purpose To find out the difference of segmental bone defect heal between bone matrix gelatin (BMG) and hydroxyapatite cement (HAC). Methods Ten millimeters long segmental defect was created in the bilateral radius in 16 New Zealand white rabbits.These defects were embedded with BMG,autologous bone and hydroxyapatite cement (HAC),and examined by radiographic,histological,scan electron microscope (SEM) and bone minal dense (BMD) within 8 weeks. Results There were obvious bone formation at all defect site at 4 weeks after operation and when at 8 weeks,all defects were repaired.The only difference between BMG and HAC was that the BMG is absorbed while the HAC was not. Conclusions At the process of segmental bone defect repairment,the effect of BMG is similar to that of autologous bone and prior to the effect of HAC,which has low absorbability.