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PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N-ETHYL-N' -NITRO-N-NITROSOGUANIDINE IN DOGS |
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| Authors: | Toshiki Kamano Noboru Azuma Atsuo Katami Junji Tamura Noburu Sakakibara Michio Matsumoto Kazuhiro Mizumoto Shunji Kitazawa Yoichi Konishi |
| Affiliation: | First Department of Surgery, Juntendo University, School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113;Second Department of Pathology, Juntendo University, School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113;Department of Oncological Pathology, Cancer Center, Nara Medical College, 840 Shijo-cho, Kashihara, Nara 634 |
| Abstract: | Pancreatic duct adenocarcinoma was induced by intraductal administration of N-ethyl-N'-nitro N-nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N-nitrosobis(2-oxo-propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs. |
| Keywords: | Pancreatic duct adenocarcinoma ENNG Dog |