Synthesis and antimicrobial activity of some new 2-indolinone derived oximes and spiro-isoxazolines |
| |
Authors: | Adel A El-Gendy Aly M Ahmedy |
| |
Affiliation: | Department of Organic Chemistry and Microbiology, Faculty of Pharmacy, Cairo University, Egypt. elgendy1@Yahoo.com |
| |
Abstract: | The synthesis and spectral analysis of some new 1,3-dihydro-3-hydroxy-3-2-hydroxyimino-2-(substituted phenyl)ethyl]-2H-indol-2-ones (21-32) and spiro3H-indol-3,5'-(4'H)-isoxazol]-2(1H)-ones (33-44) are described. Sixteen of the synthesized compounds were screened in vitro for their growth inhibitory activity against thirteen species of microorganisms, viz, S. aureus, S. epidermidis, S. faecalis, B. subtilis, B. cereus, E. aerogens, E. coli, P. aeruginosa, P. vulgaris, A. baumonia, A. faecalis, C. albicans and S. cervicae. Most of the compounds exhibited significant antimicrobial activity especially the oximes 28 and 29. |
| |
Keywords: | Indoline-2 3-dione derivatives Oximes Spiro-isoxazolines Antimicrobial activity |
本文献已被 PubMed SpringerLink 等数据库收录! |
|