Meta-analysis of the effectiveness of prophylactic antibiotics in the prevention of postoperative complications after tension-free hernioplasty |
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Authors: | Jian-Fang Li Dan-Dan Lai Xiao-Dong Zhang Ai-Min Zhang Kuan-Xue Sun Heng-Gui Luo Zhen Yu |
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Institution: | *First People’s Hospital of Xiaoshan, Hangzhou;†Department of Gastrointestinal Surgery, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China |
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Abstract: | BackgroundPrevious reviews of the effectiveness of antibiotic prophylaxis for elective inguinal hernia repair were not conclusive owing to the limited number of patients enrolled in randomized controlled trials (RCTs). However, since new RCTs involving patients undergoing tention-free hernioplasty have been published in recent years, we performed a new meta-analysis to evaluate the effectiveness of antibiotic prophylaxis in the prevention of postoperative complications after this procedure.MethodsWe performed a meta-analysis of RCTs studying the use of antibiotic prophylaxis to prevent postoperative complications in patients undergoing tension-free hernioplasty.ResultsWe included 6 RCTs conducted around the world in our analysis. Compared with the control condition, antibiotic prophylaxis was associated with a lower incidence of incision infection (odds ratio OR] 0.45, 95% confidence interval CI] 0.26–0.77, p = 0.004). There were no significant differences in risk for incision hematoma (OR 1.57, 95% CI 0.60–4.10, p = 0.35), respiratory infection (OR 1.00, 95% CI 0.17–5.79, p > 0.99) or urinary tract infection (OR 1.81, 95% CI 0.38–8.52, p = 0.45) between the 2 conditions.ConclusionAntibiotic prophylaxis use in patients undergoing tension-free hernioplasty decreases the rate of incision infection by 55%. |
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