体外反搏对冠心病患者血清IL-6及CRP水平的影响

目的观察增强型体外反搏对冠心病患者血清IL-6及CRP水平的影响,探讨体外反搏治疗冠心病的机制。方法将80例冠心病患者随机分为体外反搏治疗组40例和常规治疗组40例。两组均予常规治疗,体外反搏组每天给予45min体外反搏,3个疗程6周。分别于治疗前及治疗后6周行血清白细胞介素-6（IL-6）及C反应蛋白（CRP）检测。结果体外反搏组治疗后血清IL-6、CRP水平均明显低于治疗前（P〈0.05）;常规治疗组治疗后血清IL-6及CRP水平均无明显降低。结论体外反搏可降低冠心病患者IL-6及CRP,可能对血管内皮有保护作用。

Effect of enhanced external counterpulsation on C-reactive protein and interlukin-6 inpatients with coronary heart disease

Objective To investigate the effect of enhanced external counter pulsation (EECP) on reactive protein (CRP) and interlukin-6 (IL-6) in patients with coronary heart disease (CHD) and its mechanism. Methods The serum level of reactive protein (CRP) and interlukin-6 (IL-6) in 80 cases with CHD and 20 normal controls were tested. Patients were divided into EECP group (40 cases) and medication group (40 cases). The serum concentrations of CRP and IL-6 in each group, before and after treatment were assessed and compared for the correlation analysis. Results After 6 weeks and 3 courses EECP treatment, compared with the levels before treatment, the serum levels of CRP and IL-6 in patients with CHD, EECP group were lower significantly (P<0.05). Conclusion EECP treatment may reduce IL-6 and CRP, which maybe has the protective the blood vessel endothelium function in patients with coronary heart disease.