| 电针对大鼠脊髓损伤后caspase-3、calpastatin表达及髓鞘变化的影响 |
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| 引用本文： | 时素华,李志刚,宋金玲,郑光华,宋萌,李丽娜,许红,白丽敏. 电针对大鼠脊髓损伤后caspase-3、calpastatin表达及髓鞘变化的影响[J]. 广州中医药大学学报, 2011, 28(2): 149-154,158 |
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| 作者姓名： | 时素华 李志刚 宋金玲 郑光华 宋萌 李丽娜 许红 白丽敏 |
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| 作者单位： | 1. 北京中医药大学针灸学院,北京,100029
2. 北京中医药大学基础医学院,北京,100029 |
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| 摘 要： | [目的]观察电针治疗对大鼠脊髓损伤(SCI)后髓鞘变化及caspase-3、calpastatin表达的影响.[方法]选取雄性SD大鼠,随机分为模型组,电针组(电针大椎、命门穴),甲基强的松龙组(西药组)及空白组4组;除空白组外,其他3组大鼠均采用改良的Allen's打击装置(50 g/cm)复制大鼠T10～T11脊髓...
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| 关 键 词： | 脊髓损伤/针灸疗法 基因表达调控 脊髓/超微结构 穴,大椎 穴,命门 疾病模型,动物 大鼠 |
Effect of Electroacupuncture on mRNA Expression of Caspase-3 and Calpastatin and on Changes of Myelin Sheath in Rats with Spinal Cord Injury |
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| SHI Suhua,LI Zhigang,SONG Jinling,ZHENG Guanghua,SONG Meng,LI Lina,XU Hong,BAI Limin. Effect of Electroacupuncture on mRNA Expression of Caspase-3 and Calpastatin and on Changes of Myelin Sheath in Rats with Spinal Cord Injury[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2011, 28(2): 149-154,158 |
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| Authors: | SHI Suhua LI Zhigang SONG Jinling ZHENG Guanghua SONG Meng LI Lina XU Hong BAI Limin |
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| Affiliation: | SHI Suhua1,LI Zhigang1,SONG Jinling1,ZHENG Guanghua1,SONG Meng1,LI Lina2,XU Hong2,BAI Limin2(1.Acupuncture and Massage School,Beijing University of TCM,Beijing 100029,China,2.Basic Medical School,China) |
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| Abstract: | Objective To observe the mRNA expression of caspase-3 and calpastatin and on the changes of cell myelin sheath in rats after spinal cord injury(SCI) treated with electroacupuncture(EA).Methods SD male rats were randomized into the model group,EA group(EA on acupoints of Dazhui and Mingmen),methylprednisolone group and the blank group.Except for the blank group,rats in other groups were put into the modified Allen's apparatus(50 g/cm) to induce middle-degree T10-T11 spinal cord injury.The injured local spina... |
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| Keywords: | SPINAL CORD INJURY /acup-moxibustion therapy GENE EXPRESSION REGULATION SPINAL CORD/ultrastructure POINT GV14(DAZHUI) POINT GV4(MINGMEN) DISEASE MODELS ANIMAL RATS |
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