| 骨肉瘤组织中HER2、P-糖蛋白的表达与预后的关系 |
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| 引用本文： | 陈志伟,吴苏稼. 骨肉瘤组织中HER2、P-糖蛋白的表达与预后的关系[J]. 医学研究生学报, 2005, 18(5): 462-464 |
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| 作者姓名： | 陈志伟 吴苏稼 |
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| 作者单位： | 南京军区南京总医院,南京大学医学院临床学院,骨科,江苏南京,210002 |
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| 摘 要： | 大多数骨肉瘤均有HER2及P-糖蛋白(P—gp)的表达。P—gp介导的多药耐药性(MDR)是骨肉瘤化疗不敏感的重要原因，也是影响预后的重要因素，而致癌基因HER2的表达与否则提示肿瘤恶性程度高低及转移能力的强弱。作者拟对HER2及P-gp的表达及其与骨肉瘤预后的关系作一综述。
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| 关 键 词： | P-糖蛋白 HER2 骨肉瘤 多药耐药性 |
| 文章编号： | 1008-8199(2005)05-0462-03 |
| 修稿时间： | 2004-07-24 |
The expression of HER2 and P-gp and its prognostic significance in osteosarcoma |
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| CHEN Zhi-Wei,WU Su-jia. The expression of HER2 and P-gp and its prognostic significance in osteosarcoma[J]. Bulletin of Medical Postgraduate, 2005, 18(5): 462-464 |
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| Authors: | CHEN Zhi-Wei WU Su-jia |
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| Abstract: | HER2 and P-gp are expressed in most of the human osteosarcoma tissue. The multidrug resistance of osteosarcoma is mediated by P-gp. The insusceptibility of human osteosarcoma to chemotherapy and the poor prognosis is correlated with the expression of P-gp. The expression of the carcinogene HER2 is a prognostic risk factor of the malignancy and metastasis of osteosarcoma. The review will narrate the expression of the HER2 and P-gp in osteosarcoma and its prognostic significance. |
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| Keywords: | P-gp HER2 Osteosarcoma Multidrug resistance |
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