| 血小板活化因子对离体培养的大鼠卵巢黄体细胞孕酮分泌的影响 |
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| 引用本文： | 张承玉,金秀东,赵薇,程丹玲,朱辉.血小板活化因子对离体培养的大鼠卵巢黄体细胞孕酮分泌的影响[J].牡丹江医学院学报,2005,26(6):9-11. |
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| 作者姓名： | 张承玉 金秀东 赵薇 程丹玲 朱辉 |
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| 作者单位： | 牡丹江医学院生理教研室,157011;哈尔滨医科大学生理教研室,150086 |
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| 摘 要： | 目的:观察血小板活化因子(PAF)对离体培养的大鼠卵巢黄体细胞孕酮分泌的影响,初步探讨其可能的作用机制.方法:原代细胞培养和放免技术.结果:PAF、hCG、Forscolin、PMA组与对照组相比差异均有统计学意义(P<0.05),PAF与hCG、Forscolin、PMA交互作用均有显著性(P<0.01).结论:PAF能明显促进离体培养的大鼠卵巢黄体细胞孕酮的分泌,并且受hCG及PKA、PKC信号转导通路的调节.
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| 关 键 词： | 血小板活化因子 黄体细胞 孕酮 |
| 收稿时间： | 08 17 2005 12:00AM |
| 修稿时间： | 2005-08-17 |
EFFECT OF PLATELET ACTIVATING FACTOR ON PROGESTERONE OF LUTEIN CELLS OF RAT OVARY IN VITRO |
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| Zhang Chengyu et al..EFFECT OF PLATELET ACTIVATING FACTOR ON PROGESTERONE OF LUTEIN CELLS OF RAT OVARY IN VITRO[J].Journal of Mudanjiang Medical College,2005,26(6):9-11. |
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| Authors: | Zhang Chengyu |
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| Institution: | Teaching and researeh section of physiology,Mudanjiang Medical college 157011 |
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| Abstract: | Objective:To investigate the effect of platelet activating factor(PAF) on progesterone production by lutein cells of rat ovary in vitro,and study the mechanism.Methods:Primary cultures and radioimmunoassay.Results:Compared to the control group, the PAF, hCG, Forscolin, PMA groups had significant higher levels in lutein cells(P<0.05);PAF interacted with hCG, Forscolin and PMA significantly(P<0.01).Conclusion:PAF causes a significant increase of progesterone production in lutein cells of rat ovary in vitro;hCG and the signal transmission tracks of PKA and PKC regulate the function of PAF. |
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| Keywords: | PAF lutein cells progesterone |
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