药品不良反应224例报告分析

目的了解河南大学淮河医院药品不良反应（ADR）发生的特点,促进临床合理用药。方法对2007年1月—2009年12月收集到的224例ADR报告,分别从患者的性别、年龄、给药途径、药品类别、涉及器官或系统及主要临床表现等方面进行统计、分析。结果 224例ADR报告中,〉60岁的患者ADR发生率最高（占34.82%）;静脉给药方式是引发ADR的重要给药途径（占82.59%）;最易引起ADR的药品为抗感染药;最常见的临床表现为皮肤及其附件损害。结论应加强合理用药监测工作,减少或避免ADR发生。

ADR Reports Analysis of 224 Cases in Our Hospital

Objective To investigate the characteristics of adverse drug reactions （ADR） occurred in our hospital.Methods A total of 224 ADR cases collected from Jan 2007 to Dec 2009 in our hospital were analyzed statistically in respect of patients of gender and age,routes of administration,drug category,ADR-involved organs or systems and clinical manifestations,etc.Results Over 60 year-old patient ADR formation rate is highest （accounts for 34.82%）,82.59% of the ADR were administered by intravenous drip,and most were associated with anti-infective drugs,The ADR manifested predominantly as lesions of skin and its appendants.Conclusion Rational drug use and ADR monitoring should be strengthened to reduce or avoid the occurrence of ADR.