Bmi-1在食管癌组织中的表达及其与浸润转移的关系 |
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引用本文: | 蒋庆锋,丁志丹,陈宇航,刘先本,李印. Bmi-1在食管癌组织中的表达及其与浸润转移的关系[J]. 河南医药信息, 2010, 0(10): 29-31 |
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作者姓名: | 蒋庆锋 丁志丹 陈宇航 刘先本 李印 |
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作者单位: | 河南省肿瘤医院胸外科,郑州市450003 |
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摘 要: | 目的检测食管鳞癌组织中Bmi-1蛋白的表达,并探讨其与食管鳞癌发生及浸润转移的关系。方法应用免疫组化SP法检测50例食管鳞癌组织及其相应的28例癌旁非典型增生组织和15例正常食管黏膜组织中Bmi-1蛋白的表达。结果食管鳞癌组织中Bmi-1蛋白阳性表达率高于癌旁非典型增生组织和正常食管黏膜组织(P〈0.05);淋巴结转移组食管鳞癌组织中Bmi-1蛋白阳性表达率低于无淋巴结转移组(P〈0.05);浸润至外膜食管鳞癌组织中Bmi-1蛋白阳性表达率高于深肌层及浅肌层(P〈0.05)。结论 Bmi-1蛋白过表达可能参与食管鳞癌的发生及浸润转移过程。
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关 键 词: | 食管鳞癌Bmi-1 浸润 转移 |
Expression of Bmi-1 Protein in Esophageal Squamous Cell Carcinoma Tissue and Its Relationship with Invasion and Metastasis |
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Affiliation: | JIANG Qingfeng,DING Zhidan,CHEN Yuhang,et al Department of Thoracic Surgery,Henan Tumor Hospital,Zhengzhou 450003,China |
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Abstract: | Objective To detect the expression of Bmi-1 protein in esophageal squamous cell carcinoma(ESCC) and discuss its relationship with invasion and metastasis.Methods The expression of Bmi-1 protein in 50 cases of ESCC,28 cases of adjacent atypical hyperplasia tissue and 15 cases of normal tissue were detected by immunohistochemistry SP.Results The positive rates of Bmi-1 protein in ESCC tissue were significantly higher than those of atypical hyperplasia tissue and normal tissue(P0.05);In metastatic group,the positive rates of Bmi-1 protein in ESCC tissue were higher than those in non-metastatic group(P0.05);The positive rates of Bmi-1 protein in ESCC tissue in outer layer invaded were higer than those in superficial-muscle invaded group and in deep-muscle invaded group(P0.05).Conclusion Overexpressions of Bmi-1 protein are possible to participate in occurrence and invasion and metastasis of ESCC. |
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Keywords: | Esophageal squamous cell carcinoma Bmi-1 Invasion Metastasis |
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