Bmi-1在食管癌组织中的表达及其与浸润转移的关系

目的检测食管鳞癌组织中Bmi-1蛋白的表达,并探讨其与食管鳞癌发生及浸润转移的关系。方法应用免疫组化SP法检测50例食管鳞癌组织及其相应的28例癌旁非典型增生组织和15例正常食管黏膜组织中Bmi-1蛋白的表达。结果食管鳞癌组织中Bmi-1蛋白阳性表达率高于癌旁非典型增生组织和正常食管黏膜组织（P〈0.05）;淋巴结转移组食管鳞癌组织中Bmi-1蛋白阳性表达率低于无淋巴结转移组（P〈0.05）;浸润至外膜食管鳞癌组织中Bmi-1蛋白阳性表达率高于深肌层及浅肌层（P〈0.05）。结论 Bmi-1蛋白过表达可能参与食管鳞癌的发生及浸润转移过程。

Expression of Bmi-1 Protein in Esophageal Squamous Cell Carcinoma Tissue and Its Relationship with Invasion and Metastasis

Objective To detect the expression of Bmi-1 protein in esophageal squamous cell carcinoma（ESCC） and discuss its relationship with invasion and metastasis.Methods The expression of Bmi-1 protein in 50 cases of ESCC,28 cases of adjacent atypical hyperplasia tissue and 15 cases of normal tissue were detected by immunohistochemistry SP.Results The positive rates of Bmi-1 protein in ESCC tissue were significantly higher than those of atypical hyperplasia tissue and normal tissue（P0.05）;In metastatic group,the positive rates of Bmi-1 protein in ESCC tissue were higher than those in non-metastatic group（P0.05）;The positive rates of Bmi-1 protein in ESCC tissue in outer layer invaded were higer than those in superficial-muscle invaded group and in deep-muscle invaded group（P0.05）.Conclusion Overexpressions of Bmi-1 protein are possible to participate in occurrence and invasion and metastasis of ESCC.