阿立哌唑与利培酮治疗女性精神分裂症的对照分析

目的比较阿立哌唑与利培酮对女性精神分裂症患者的疗效和不良反应。方法把符合入组条件的64例女性患者随机分成2组,分别给予阿立哌唑和利培酮治疗,研究观察8周。于治疗后2、4、6、8周末用阳性症状与阴性症状量表（PANSS）和副反应量表（TESS）评定疗效和不良反应。结果治疗后2组患者PANSS评分均有明显下降（P〈0.01）。阿立哌唑组痊愈率25%,有效率90.63%,利培酮组痊愈率28.1%,有效率93.75%,两组间疗效无明显性差异（P〉0.05）。两组患者副反应主要表现在头昏、兴奋激越、恶心呕吐、锥体外系副反应、心电图异常、嗜睡、失眠、便秘、体重增加和泌乳月经紊乱等方面,其中锥体外系副反应、体重增加和泌乳、月经紊乱3方面的副反应阿立哌唑组明显小于利培酮组（P〈0.05）。结论阿立哌唑和利培酮对女性精神分裂症患者疗效相当,阿立哌唑在体重增加、锥体外系副反应和泌乳月经紊乱等方面的副反应小于利培酮。

Comparative Study on Aripiprazole and Risperidone in Treatment of Female Patients with Schizophrenics

Objective To compare the efficacy and side effect of aripiprazole and risperidone in the treatment of female patients with schizophrenics.Methods Totally 64 female patients with schizophrenics were randomly divided into aripiprazole group and risperidone group,efficacy and side effect were assessed with PANSS and TESS at before and the ends of the 2nd.4th.6th and 8th week of the treatment.Results there were obvious curative effect with all patients after treatment （P0.01）,the total effective rates of aripiprazole group and risperidone group were 90.63% and 93.75%,there was no significant difference between two groups （P0.05）.The side effect of risperidone was obviously than aripiprazole in weight up,extraphramidal,secrete breast and menstrual disorder.Conclusion The curative effect of aripiprazole and risperidone was same in treatment of female patients with schizophrenics.The side effect of aripiprazole in weight up,extraphramidal,secrete breast and menstrual disorder was lower than risperidone.