| 湖南省细菌耐药监测网2012—2021年铜绿假单胞菌耐药性监测报告 |
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| 引用本文： | 刘健龙,宋春荣,付敏,胡琼,陈丽华,付陈超,李晨,李艳明,刘君,宁兴旺,石国民,邬靖敏,杨怀德,袁红霞,郑铭,黄勋,吴安华,任南. 湖南省细菌耐药监测网2012—2021年铜绿假单胞菌耐药性监测报告[J]. 中国感染控制杂志, 2023, 0(12): 1452-1459 |
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| 作者姓名： | 刘健龙 宋春荣 付敏 胡琼 陈丽华 付陈超 李晨 李艳明 刘君 宁兴旺 石国民 邬靖敏 杨怀德 袁红霞 郑铭 黄勋 吴安华 任南 |
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| 作者单位： | 1.湖南省儿童医院检验中心, 湖南 长沙 410007;2.中南大学湘雅三医院检验科, 湖南 长沙 410013;3.中南大学湘雅医院医院感染控制中心, 湖南 长沙 410008;4.湖南省细菌耐药监测网办公室, 湖南 长沙 410008;5.浏阳市中医医院检验科, 湖南 浏阳 410300;6.中南大学湘雅医院检验科, 湖南 长沙 410008;7.湘潭市中心医院检验科, 湖南 湘潭 411100;8.湖南中医药大学第一附属医院医学检验与病理中心, 湖南 长沙 410007;9.长沙市中心医院检验科, 湖南 长沙 410004;10.长沙市第一医院检验科, 湖南 长沙 410005;11.张家界市人民医院检验科, 湖南 张家界 427000;12.郴州市第一人民医院检验医学中心, 湖南 郴州 423000;13.湖南省医院感染管理质量控制中心, 湖南 长沙 410008;14.国家老年疾病临床医学研究中心(湘雅医院), 湖南 长沙 410008 |
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| 基金项目： | 湖南省自然科学基金项目（NO01JJY2119）;湖南省自然科学基金-科卫联合项目（2023JJ60011）;"感·动中国"医疗机构感染预防与控制科研项目（GY2023013-A） |
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| 摘 要： | 目的 了解2012—2021年湖南省细菌耐药监测网监测医院临床分离铜绿假单胞菌的分布及耐药性变迁情况。方法 采用纸片扩散法或自动化仪器法对临床分离株作药物敏感性(药敏)试验，按美国临床实验室标准化协会(CLSI)2022年版标准判断药敏试验结果，并应用WHONET 5.6软件进行统计分析。应用SPSS对数据进行趋势性检验(Cochran-armitage)及卡方检验。结果 2012—2021年湖南省耐药监测网共监测铜绿假单胞菌176 441株，其中，99.4%的菌株分离自住院患者，约70%的菌株分离自呼吸道标本；儿童(0～17岁)来源的铜绿假单胞菌占8.4%,成人来源的占91.6%。药敏结果显示，10年间铜绿假单胞菌对多黏菌素B最敏感，耐药率低于6%,对哌拉西林、哌拉西林/他唑巴坦、头孢他啶、头孢吡肟、氨曲南、亚胺培南、阿米卡星、庆大霉素、妥布霉素、环丙沙星、左氧氟沙星、多黏菌素B的耐药率均呈下降趋势。共检出耐碳青霉烯类铜绿假单胞菌(CRPA)29 920株，该省CRPA 10年的平均分离率为18.0%。成人CRPA检出率为18.5%,高于儿童的12.3%,均呈下降趋势。结论 湖南省临...
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| 关 键 词： | 细菌 抗菌药物 铜绿假单胞菌 耐药性 监测 湖南省细菌耐药监测网 |
| 收稿时间： | 2023-10-10 |
Antimicrobial resistance of Pseudomonas aeruginosa: surveillance report from Hunan Provincial Antimicrobial Resistance Surveillance System, 2012-2021 |
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| Jian-long LIU,Chun-rong SONG,Min FU,Qiong HU,Li-hua CHEN,Chen-chao FU,Chen LI,Yan-ming LI,Jun LIU,Xing-wang NING,Guo-min SHI,Jing-min WU,Huai-de YANG,Hong-xia YUAN,Ming ZHENG,Xun HUANG,An-hua WU,Nan REN. Antimicrobial resistance of Pseudomonas aeruginosa: surveillance report from Hunan Provincial Antimicrobial Resistance Surveillance System, 2012-2021[J]. Chinese Journal of Infection Control, 2023, 0(12): 1452-1459 |
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| Authors: | Jian-long LIU Chun-rong SONG Min FU Qiong HU Li-hua CHEN Chen-chao FU Chen LI Yan-ming LI Jun LIU Xing-wang NING Guo-min SHI Jing-min WU Huai-de YANG Hong-xia YUAN Ming ZHENG Xun HUANG An-hua WU Nan REN |
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| Affiliation: | 1.Laboratory Center, Hunan Children''s Hospital, Changsha 410007, China;2.Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha 410013, China;3.Center for Healthcare-associated Infection Control, Xiang-ya Hospital, Central South University, Changsha 410008, China;4.Hunan Provincial Antimicrobial Resistance Surveillance System Office, Changsha 410008, China;5.Department of Laboratory Medicine, Liuyang Traditional Chinese Medicine Hospital, Liuyang 410300, China;6.Department of Laboratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China;7.Department of Laboratory Medicine, Xiangtan Central Hospital, Xiangtan 411100, China;8.Medical Laboratory and Pathology Center, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China;9.Department of Laboratory Medicine, Changsha Central Hospital, Changsha 410004, China;10.Department of Laboratory Medicine, The First Hospital of Changsha, Changsha 410005, China;11.Department of Laboratory Medicine, Zhangjiajie People''s Hospital, Zhangjiajie 427000, China;12.Center of Laboratory Medicine, The First People''s Hospital of Chenzhou, Chenzhou 423000, China;13.Hunan Provincial Healthcare-associated Infection Management Quality Control Center, Changsha 410008, China;14.National Clinical Research Center for Geriatric Disorders[Xiangya Hospital], Changsha 410008, China |
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| Abstract: | Objective To understand the distribution and changes in antimicrobial resistance of clinically isolated Pseudomonas aeruginosa (P. aeruginosa) in the member hospitals of Hunan Provincial Antimicrobial Resistance Surveillance System from 2012 to 2021. Methods Antimicrobial susceptibility testing by disk diffusion or automated instrument was performed on clinical isolates. Testing results were determined according to the standards of 2022 edition from American Clinical Laboratory Standards Institute (CLSI). Statistical analysis was performed by WHONET 5.6 software. Data were analyzed by trend test (Cochran-armitage) and Chi-square test with SPSS. Results A total of 176 441 strains of P. aeruginosa were surveilled by Hunan Provincial Antimicrobial Resistance Surveillance System from 2012 to 2021. 99.4% of the strains were isolated from hospitalized patients, and about 70% of the strains were isolated from respiratory specimens. 8.4% of P. aeruginosa were from children (0-17 years old), 91.6% were from adults. Antimicrobial susceptibility testing results showed that P. aeruginosa was most sensitive to polymyxin B over 10 years, with a resis-tance rate of less than 6%. Resistance rates to piperacillin, piperacillin/tazobactam, ceftazidime, cefepime, aztreonam, imipenem, amikacin, gentamicin, tobramycin, ciprofloxacin, levofloxacin, and polymyxin B all showed downward trends. A total of 29 920 carbapenem-resistant P. aeruginosa (CRPA) strains were detected. The average isolation rate of CRPA in this province was 18.0% over 10 years. CRPA detection rate from adult was 18.5%, higher than that from children (12.3%), and both showing downward trends. Conclusion The resistance rate of clinically isolated P. aeruginosa in Hunan Province to most commonly used antimicrobial agents is decreasing. |
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| Keywords: | bacteria antimicrobial agent Pseudomonas aeruginosa antimicrobial resistance surveillance Hunan Provincial Antimicrobial Resistance Surveillance System |
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